Evidence map›Paper›PMID 32576651›Full record

ArticlemSystems2020

High-Resolution Longitudinal Dynamics of the Cystic Fibrosis Sputum Microbiome and Metabolome through Antibiotic Therapy.

Ruma Raghuvanshi, Karla Vasco, Yoshiki Vázquez-Baeza, Lingjing Jiang, James T Morton, Danxun Li, Antonio Gonzalez, Lindsay DeRight Goldasich, Gregory Humphrey, Gail Ackermann and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Bridging bench and bedside: translational omics ofEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Mutations in thebioRxiv : the preprint server for biology · 2024
    Article
  13. Observational
  14. Article
  15. Article
  16. Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024
    Article
  17. The presence of cystic fibrosis-related diabetes modifies the sputum microbiome in cystic fibrosis disease.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  18. Co-occurring microflora and mucin driveISME communications · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Ruma Raghuvanshi *Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
Karla Vasco *Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
Yoshiki Vázquez-BaezaDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Lingjing JiangDivision of Biostatistics, University of California San Diego, La Jolla, California, USA.
James T MortonCenter for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, USA.
Danxun LiCenter for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, USA.
Antonio GonzalezDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Lindsay DeRight GoldasichDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Gregory HumphreyDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Gail AckermannDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Austin D SwaffordCenter for Microbiome Innovation, University of California San Diego, La Jolla, California, USA.
Douglas ConradDepartment of Medicine, University of California San Diego, La Jolla, California, USA dconrad@ucsd.edu rknight@ucsd.edu pdorrestein@ucsd.edu quinnrob@msu.edu.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA dconrad@ucsd.edu rknight@ucsd.edu pdorrestein@ucsd.edu quinnrob@msu.edu.ORCID https://orcid.org/0000-0002-0975-9019
Pieter C DorresteinCenter for Microbiome Innovation, University of California San Diego, La Jolla, California, USA dconrad@ucsd.edu rknight@ucsd.edu pdorrestein@ucsd.edu quinnrob@msu.edu.
Robert A QuinnDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA dconrad@ucsd.edu rknight@ucsd.edu pdorrestein@ucsd.edu quinnrob@msu.edu.
University of California San Diego · USMichigan State University · USSimons Foundation · US

Funding

Determining How a Dynamic Microbiome Contributes to Cystic Fibrosis Lung DiseaseR01AI145925 · NIAID · MICHIGAN STATE UNIVERSITY · PI QUINN, ROBERT ANDREW · 2019 to 2022
$2.7M
NIAID NIH HHS R01 AI145925
6 · The paper itself

Abstract

Microbial diversity in the cystic fibrosis (CF) lung decreases over decades as pathogenic bacteria such as

Indexed as

antibioticscystic fibrosismetabolomemicrobiome

Identifiers

PMID32576651
PMCPMC7311317
OpenAlexW3036188175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.