Evidence map›Paper›PMID 32576620›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity.

Min Lin, Luis M Colon-Perez, Danielle O Sambo, Douglas R Miller, Joseph J Lebowitz, Felix Jimenez-Rondan, Robert J Cousins, Nicole Horenstein, Tolunay Beker Aydemir, Marcelo Febo and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 68 citations in OpenAlex.

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  17. Manganese-driven CoQ deficiency.Nature communications · 2022
    Article
  18. Manganese-Induced Toxicity inInternational journal of molecular sciences · 2022
    Article
  19. Therapeutic Effects of Quetiapine and 5-HTInternational journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Min LinDepartment of Neuroscience, University of Florida, Gainesville, Florida 32611.
Luis M Colon-PerezDepartment of Psychiatry, University of Florida, Gainesville, Florida 32611.
Danielle O SamboDepartment of Neuroscience, University of Florida, Gainesville, Florida 32611.
Douglas R MillerDepartment of Neuroscience, University of Florida, Gainesville, Florida 32611.
Joseph J LebowitzDepartment of Neuroscience, University of Florida, Gainesville, Florida 32611.
Felix Jimenez-RondanCenter for Nutritional Sciences, University of Florida, Gainesville, Florida 32611.
Robert J CousinsCenter for Nutritional Sciences, University of Florida, Gainesville, Florida 32611.
Nicole HorensteinDepartment of Chemistry, University of Florida, Gainesville, Florida 32611.
Tolunay Beker AydemirDivision of Nutritional Sciences, Cornell University, Ithaca, New York 14853.
Marcelo FeboDepartment of Psychiatry, University of Florida, Gainesville, Florida 32611.
Habibeh KhoshboueiDepartment of Neuroscience, University of Florida, Gainesville, Florida 32611 Habibeh@ufl.edu.ORCID 0000-0002-1533-8771
University of Florida · USCornell University · US

Funding

Alpha-synuclein Regulates Dopamine Transporter FunctionsR01NS071122 · NINDS · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH · 2010 to 2022
$3.9M
Methamphetamine regulates the dopamine transporter via an intracellular mechanismR01DA026947 · NIDA · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH · 2010 to 2019
$3.5M
Interactions between microglia and dopaminergic neurons regulates dopamine neurotransmissionR21DA043895 · NIDA · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH, STREIT, WOLFGANG J · 2017 to 2018
$415k
NIDA NIH HHS R01 DA026947NIDA NIH HHS R21 DA043895NINDS NIH HHS R01 NS071122
6 · The paper itself

Abstract

Manganese exposure produces Parkinson's-like neurologic symptoms, suggesting a selective dysregulation of dopamine transmission. It is unknown, however, how manganese accumulates in dopaminergic brain regions or how it regulates the activity of dopamine neurons. Our

Indexed as

Action PotentialsAnimalsCells, CulturedDopaminergic NeuronsDose-Response Relationship, DrugHEK293 CellsHumansMaleManganeseMiceMice, Inbred C57BLOrgan Culture TechniquesManganesedopamine neuronsL-type calcium channelmanganeseParkinson's diseasesynaptic transmission

Identifiers

PMID32576620
PMCPMC7380961
OpenAlexW3037936818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.