Evidence map›Paper›PMID 32576602›Full record

ArticleLife science alliance2020

EBV renders B cells susceptible to HIV-1 in humanized mice.

Donal McHugh, Renier Myburgh, Nicole Caduff, Michael Spohn, Yik Lim Kok, Christian W Keller, Anita Murer, Bithi Chatterjee, Julia Rühl, Christine Engelmann and 24 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

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  14. HIV co-infection augments EBV-induced tumorigenesisFrontiers in virology (Lausanne, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 5 institutions in 4 countries.

Donal McHughViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-3791-0038
Renier MyburghDepartment of Medical Oncology and Hematology, University and University Hospital of Zürich, Zürich, Switzerland.
Nicole CaduffViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-7479-5446
Michael SpohnHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Yik Lim KokDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Christian W KellerNeuroinflammation, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Anita MurerViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Bithi ChatterjeeViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Julia RühlViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Christine EngelmannViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Obinna ChijiokeCellular Immunotherapy, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0000-0003-4247-5947
Isaak QuastNeuroinflammation, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Mohaned ShilaihDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Victoria P StrouvelleDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Kathrin NeumannDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Thomas MenterInstitute of Pathology and Medical Genetics, University Hospital of Basel, Basel, Switzerland.ORCID 0000-0002-0847-6156
Stephan DirnhoferInstitute of Pathology and Medical Genetics, University Hospital of Basel, Basel, Switzerland.
Janice Kp LamDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0000-0001-7414-2026
Kwai F HuiDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0000-0002-5572-8395
Simon BredlDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Erika SchlaepferDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Silvia SorceInstitute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland.
Andrea ZbindenInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.
Riccarda CapaulInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.
Jan D LünemannNeuroinflammation, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Adriano AguzziInstitute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland.ORCID 0000-0002-0344-6708
Alan Ks ChiangDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.ORCID 0000-0002-1089-5325
Werner KempfKempf und Pfaltz Histologische Diagnostik AG, Zürich, Switzerland.ORCID 0000-0002-6552-8629
Alexandra TrkolaInstitute of Medical Virology, University of Zürich, Zürich, Switzerland.
Karin J MetznerDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.ORCID 0000-0003-4862-1503
Markus G ManzDepartment of Medical Oncology and Hematology, University and University Hospital of Zürich, Zürich, Switzerland.ORCID 0000-0002-4676-7931
Adam GrundhoffHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Roberto F SpeckDivision of Infectious Diseases and Hospital Epidemiology, University Hospital of Zürich, Zürich, Switzerland.
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland christian.muenz@uzh.ch.ORCID 0000-0001-6419-1940
University of Zurich · CHUniversity Hospital of Zurich · CHQueen Mary Hospital · CNLeibniz Institute of Virology (LIV) · DEUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4

Indexed as

AnimalsB-LymphocytesCD4 AntigensCoinfectionDisease Models, AnimalDisease SusceptibilityEpstein-Barr Virus InfectionsHematopoietic Stem CellsHerpesvirus 4, HumanHIV-1HIV InfectionsHIV SeropositivityHumansMaleMiceMice, Inbred NODCD4 AntigensCXCR4 protein, humanReceptors, CXCR4

Identifiers

PMID32576602
PMCPMC7335381
OpenAlexW3037596176

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.