ArticleHematology, transfusion and cell therapy
Impact of neuropathic pain on quality of life in adults with sickle cell disease: observational study.
Article in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Association of depression and hydroxyurea use with neuropathic pain in hemoglobinopathies.Scientific reports · 2025Article
- WHOQOL-BREF in Measuring Quality of Life Among Sickle Cell Disease Patients with Leg Ulcers.International journal of environmental research and public health · 2025Article
- Preliminary construct validity of patient-reported outcomes to assess chronic pain in adults with sickle cell disease.Blood advances · 2023Article
- Prevalence of neuropathic pain in adolescents with sickle cell disease: A single-center experience.Pediatric blood & cancer · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionKnowledge on the characteristics of neuropathic pain in people with sickle cell disease (SCD) may help to provide more effective treatment procedures.
objectiveTo describe the characteristics of neuropathic pain in patients with sickle cell disease and identify the impact on their quality of life.
methodA cross-sectional study (CAAE 57274516.8.0000.5544) was conducted at a reference center in Salvador, Bahia, Brazil. The instruments used were the Brief Pain Inventory (BPI), the Douleur Neuropatique Questionnaire (DN-4), the Anxiety and Depression Hospital scale (ADH) and the abbreviated version of the World Health Organization of Quality of Life questionnaire (WHOQOL-brief). The Mann-Whitney test was used to evaluate the association between the scores (5% alpha).
resultsA total of 100 adults with SCD participated in the study, 69.7% of whom had neuropathic pain. Anxiety was present in 99% of the sample and depression, in 100%. Patients with neuropathic pain had worse scores in all domains of quality of life (p < 0.05), but no association was found with pain intensity.
conclusionNeuropathic pain was more frequent than nociceptive pain in adults with SCD and generated worse scores in all domains of quality of life. Anxiety and depression were present in patients with both types of pain.
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