Evidence map›Paper›PMID 32576186›Full record

ArticleMalaria journal2020

Asymptomatic carriage of Plasmodium falciparum by individuals with variant blood groups and haemoglobin genotypes in southern Ghana.

Festus K Acquah, Dickson Donu, Dorcas Bredu, Sophia Eyia-Ampah, Jones A Amponsah, Joseph Quartey, Evans K Obboh, Bernice A Mawuli, Linda E Amoah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Festus K AcquahImmunology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana.
Dickson DonuImmunology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana.
Dorcas BreduImmunology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana.
Sophia Eyia-AmpahImmunology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana.
Jones A AmponsahImmunology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana.
Joseph QuarteyParasitology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana.
Evans K ObbohSchool of Medical Sciences, University of Cape Coast, PMB, Cape Coast, Ghana.
Bernice A MawuliWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Volta Road, Legon, P.O. Box LG 54, Accra, Ghana.
Linda E AmoahImmunology Department, Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, P. O. Box LG 581, Accra, Ghana. Lek.amoah@gmail.com.ORCID http://orcid.org/0000-0002-1652-8489
University of Ghana · GHUniversity of Cape Coast · GH

Funding

World Bank Group ACE02-WACCBIP
6 · The paper itself

Abstract

backgroundThe ABO and the Rhesus blood group systems, as well as various abnormal haemoglobin (Hb) variants (haemoglobinopathies) are known to influence malaria parasite carriage and disease severity in individuals living in malaria endemic areas. This study identified the blood group and Hb variant distribution and Plasmodium falciparum infection status of afebrile individuals living in southern Ghana.

methodsAfebrile participants were recruited from Obom (358) in the Greater Accra Region and Ewim (100) and Simiw (329) in the Central Region of Ghana. Venous blood (1 ml) was collected into EDTA vacutainer tubes. Three 20 μl drops of blood were used for blood group analysis using the tile method. Another 500 μl aliquot was used for the qualitative sickling test using sodium metabisulphite and haemoglobin electrophoresis. Genomic DNA was extracted from 100 μl of whole blood and used in P. falciparum species-specific PCR.

resultsThe most abundant blood group and abnormal haemoglobin variant in both sites was blood group O + (47.4%) and HbAS (15.8%). A total of 13 (1.7%) of the participants had full haemoglobinopathies (SS, SC and CC), whilst 196 (25.4%) were carriers (AS and AC). Although there was a significantly higher prevalence of sickling positive participants from the Central Region, genotyping identified a similar prevalence of each of the abnormal haemoglobin genes in both sites. Asymptomatic parasite carriage estimated by PCR was 40.9% in the Central Region and 41.8% in the Greater Accra Region.

conclusionsAsymptomatic carriage of P. falciparum parasite in the study population was not associated with any particular blood group variant or haemoglobin genotype.

Indexed as

GenotypeAdolescentAdultAgedAged, 80 and overBlood Group AntigensCarrier StateChildChild, PreschoolCross-Sectional StudiesFemaleGhanaHemoglobinsHumansInfantInfant, NewbornBlood Group AntigensHemoglobins

Identifiers

PMID32576186
PMCPMC7310487
OpenAlexW3035861684

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.