Evidence map›Paper›PMID 32576094›Full record

ArticleEmerging microbes & infections2020

The activation of antiviral RNA interference not only exists in neural progenitor cells but also in somatic cells in mammals.

Yuqiang Zhang, Zhe Li, Zhi Ye, Yan Xu, Binbin Wang, Congcong Wang, Yunpeng Dai, Jinfeng Lu, Boxun Lu, Wanju Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Mammalian viral suppressors of RNA interference.Trends in biochemical sciences · 2022
    Review
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yuqiang ZhangState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Zhe LiState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Zhi YeState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Yan XuState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Binbin WangState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Congcong WangState Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University, Shanghai, China.
Yunpeng DaiState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Jinfeng LuInstitute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Boxun LuState Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-1675-9340
Wanju ZhangDepartment of Pathogen Diagnosis and Biosafety, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yang LiState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Fudan University · CNColumbia University · USShanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA interference (RNAi) pathway directs an important antiviral immunity mechanism in plants and invertebrates. Recently, we and others have demonstrated that the antiviral RNAi response is also conserved in mammals, at least to five distinct RNA viruses, including Zika virus (ZIKV). ZIKV may preferentially infect neuronal progenitor cells (NPCs) in the developing foetal brain.

Indexed as

AlphavirusAlphavirus InfectionsAnimalsCell DifferentiationCell LineCentral Nervous SystemChlorocebus aethiopsHEK293 CellsHumansMiceMuscle, SkeletalNeural Stem CellsRNA, Small InterferingRNA, ViralSindbis VirusVero CellsRNA, Small InterferingRNA, Viralantiviral immune responseantiviral RNA interferenceimmune-compromised micemosquito-borne virusespathogenesis of ZIKVvirus clearancevirus-encoded suppressors of RNA interferenceZika virus

Identifiers

PMID32576094
PMCPMC7473182
OpenAlexW3038112738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.