Evidence map›Paper›PMID 32576023›Full record

ArticleAIDS care2020

Healthcare provider knowledge and attitudes about pre-exposure prophylaxis (PrEP) in pregnancy in Cape Town, South Africa.

Dvora L Joseph Davey, Joseph Daniels, Cindy Beard, Nyiko Mashele, Linda-Gail Bekker, Kathryn Dovel, Jabulani Ncayiyana, Thomas J Coates, Landon Myer

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in AIDS care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03902418 (Evaluation of Pre-Exposure Prophylaxis), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03902418 completednot on this map

Evaluation of Pre-Exposure Prophylaxis (PrEP) Initiation, Retention, and Adherence in Pregnant and Breastfeeding Women

TypeobservationalSponsorUniversity of California, Los AngelesRan2019 to 2024Enrolled1,195ConditionsHIV-I InfectionArmsemtricitabine/tenofovir
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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  17. "Journal of the International Association of Providers of AIDS Care
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Dvora L Joseph DaveyDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.ORCID 0000-0001-6290-9293
Joseph DanielsDepartment of Psychiatry and Human Behaviors, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
Cindy BeardDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Nyiko MasheleDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Linda-Gail BekkerDesmond Tutu HIV Foundation, Cape Town, South Africa.ORCID 0000-0002-0755-4386
Kathryn DovelDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5622-3401
Jabulani NcayiyanaDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-2151-1251
Thomas J CoatesDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Landon MyerDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAUniversity of California, Los Angeles · USCharles R. Drew University of Medicine and Science · USDesmond Tutu HIV Foundation · ZA

Funding

Evaluating the PrEP cascade in HIV-negative pregnant and breastfeeding women in South Africa (PrEP-PP)R01MH116771 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH DAVEY, DVORA LEAH, MYER, BENJAMIN LANDON · 2018 to 2022
$2.5M
Evaluation of pre-exposure prophylaxis cascade in pregnant and breastfeeding women in Cape Town, South AfricaK01TW011187 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH DAVEY, DVORA LEAH · 2018 to 2022
$698k
FIC NIH HHS K01 TW011187NIMH NIH HHS R01 MH116771
6 · The paper itself

Abstract

Pre-exposure prophylaxis (PrEP) in pregnancy can reduce HIV incidence and vertical transmission. Healthcare providers (HCPs) play a critical role in delivering PrEP in antenatal care but little is known about HCP knowledge and attitudes about PrEP in pregnancy. We conducted a qualitative study in two healthcare facilities to assess HCPs' PrEP knowledge and perspectives relating to HIV prevention in pregnant women. Between January-March'19, we administered in-depth interviews among antenatal HCPs. We utilized a constant comparison approach to identify major qualitative findings. We enrolled 35 female HCPs (median age=43yrs. Fewer than half of HCPs had heard of PrEP before. Of those who had heard of PrEP, most felt that it was safe to take during pregnancy. Most HCPs described inaccurate PrEP knowledge regarding effectiveness, and most who knew about PrEP lacked clinical detail. HCPs highlighted important potential barriers to maternal PrEP use including: fear that PrEP may be unsafe, or belief that women must talk to partners/parents before initiating PrEP. Facilitators include good knowledge about serodiscordancy and vulnerability to seroconversion in pregnancy and desire to help women gain control overHIV prevention. We recommend integrating PrEP training into HIV testing and PMTCT nurse training to improve counseling and maternal PrEP delivery.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisFemaleHealth Knowledge, Attitudes, PracticeHealth PersonnelHumansInfectious Disease Transmission, VerticalMalePregnancySouth AfricaAnti-HIV Agentshealthcare providersHIV preventionPMTCTPregnancyPrEPSouth Africa

Identifiers

PMID32576023
PMCPMC7529982
OpenAlexW3037953843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.