Evidence map›Paper›PMID 32575985›Full record

ArticleJournal of medicinal chemistry2020

Novel Thienopyrimidine Inhibitors of

Andrew S Bell, Zhiyong Yu, Jennie A Hutton, Megan H Wright, James A Brannigan, Daniel Paape, Shirley M Roberts, Charlotte L Sutherell, Markus Ritzefeld, Anthony J Wilkinson and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. New Thieno[3,2-Life (Basel, Switzerland) · 2026
    Article
  3. Silver-Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Fatty Acid Composition and Metabolism inInternational journal of molecular sciences · 2023
    Review
  9. Selene-Ethylenelacticamides andPathogens (Basel, Switzerland) · 2023
    Article
  10. Identification of PotentialMetabolites · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Andrew S BellDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.ORCID 0000-0002-0581-9387
Zhiyong YuDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.
Jennie A HuttonDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.
Megan H WrightSchool of Chemistry, University of Leeds, Leeds, U.K. LS2 9JT.ORCID 0000-0003-2731-4707
James A BranniganStructural Biology Laboratory, York Biomedical Research Institute, Department of Chemistry, University of York, York, U.K. YO10 5DD.ORCID 0000-0001-6597-8972
Daniel PaapeCentre for Immunology and Infection, York Biomedical Research Institute, Department of Biology, University of York, York, U.K. YO10 5NG.
Shirley M RobertsStructural Biology Laboratory, York Biomedical Research Institute, Department of Chemistry, University of York, York, U.K. YO10 5DD.
Charlotte L SutherellDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.ORCID 0000-0001-5987-4149
Markus RitzefeldDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.ORCID 0000-0002-9898-4110
Anthony J WilkinsonStructural Biology Laboratory, York Biomedical Research Institute, Department of Chemistry, University of York, York, U.K. YO10 5DD.
Deborah F SmithCentre for Immunology and Infection, York Biomedical Research Institute, Department of Biology, University of York, York, U.K. YO10 5NG.
Robin J LeatherbarrowDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.
Edward W TateDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, London, U.K. W12 0BZ.ORCID 0000-0003-2213-5814
Imperial College London · GBUniversity of York · GBUniversity of Leeds · GB

Funding

Wellcome TrustWellcome Trust 087792
6 · The paper itself

Abstract

The leishmaniases, caused by

Indexed as

AcyltransferasesAntiprotozoal AgentsBinding SitesEnzyme InhibitorsLeishmania donovaniLeishmania majorMolecular StructureParasitic Sensitivity TestsProtein BindingProtozoan ProteinsPyrimidinesStructure-Activity RelationshipThiophenesAcyltransferasesAntiprotozoal AgentsEnzyme InhibitorsProtozoan ProteinsPyrimidinesThiophenes

Identifiers

PMID32575985
PMCPMC7383931
OpenAlexW3037838748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.