ArticleJournal of the American Chemical Society2020
Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins.
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Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- The Shape of Things to Come: α-Helical Membrane Protein Folding on the Ribosome.Chemical reviews · 2026Review
- Milk Fat Globule Membrane: Structural Organization, Bioactive Constituents, and Therapeutic Applications.Foods (Basel, Switzerland) · 2026Review
- Detergent-free isolation and characterization of amyloid precursor protein C99 in E. coli native lipid-nanodiscs using non-ionic polymer.Protein science : a publication of the Protein Society · 2025Article
- Monitoring of Bicelles Spreading into Floating Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Solid-state NMR of membrane peptides and proteins in the lipid cubic phase.Biophysical journal · 2025Article
- Cell-Free Systems and Their Importance in the Study of Membrane Proteins.The Journal of membrane biology · 2025Review
- Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease.Annual review of biophysics · 2024Review
- Peptoid-based macrodiscs of variable lipid composition for structural studies of membrane proteins by oriented-sample solid-state NMR.Journal of structural biology: X · 2024Article
- Characterization of nanodisc-forming peptides for membrane protein studies.Journal of colloid and interface science · 2024Article
- Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.PLoS genetics · 2023Article
- Article
- Enhancing the stability and homogeneity of non-ionic polymer nanodiscs by tuning electrostatic interactions.Journal of colloid and interface science · 2023Article
- Article
- The Interaction of Anthracycline Based Quinone-Chelators with Model Lipid Membranes:Membranes · 2023Article
- Formation of extramembraneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Holmium Complex with Phospholipids asMolecules (Basel, Switzerland) · 2022Article
- Mass Spectrometry Methods for Measuring Protein Stability.Chemical reviews · 2022Review
- Review
- Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability.Journal of lipid research · 2022Article
- The transmembrane amyloid precursor C99 protein exhibits non-specific interaction with tau.Biochemical and biophysical research communications · 2021Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 2 countries.
James M HutchisonChemical and Physical Biology Graduate Program and Center for Structural Biology, Vanderbilt University, Nashville 37240, Tennessee, United States.
Kuo-Chih ShihPolymer Program, Department of Chemical & Biomolecular Engineering, and Department of Biomedical Engineering, University of Connecticut, Storrs 06269, Connecticut, United States.
Holger A ScheidtInstitute for Medical Physics and Biophysics, Leipzig University, Leipzig 16-18, 04107, Germany.
Sarah M FantinDepartment of Chemistry, University of Michigan, Ann Arbor 48109, Michigan, United States.
Kristine F ParsonDepartment of Chemistry, University of Michigan, Ann Arbor 48109, Michigan, United States.
George A PantelopulosDepartment of Chemistry, Boston University, Boston 02215, Massachusetts, United States.
Haley R HarringtonCenter for Structural Biology and Department of Biochemistry, Vanderbilt University School of Medicine Basic Sciences, Nashville 37240, Tennessee, United States.
Kathleen F MittendorfCenter for Health Research, Kaiser Permanente, Portland 97227, Oregon, United States.
Shuo QianNeutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge 37831, Tennessee, United States.ORCID 0000-0002-4842-828X
Richard A SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville37240, Tennessee, United States.
Scott E CollierDepartment of Translational and Applied Genomics, Center for Health Research, Kaiser Permanente Northwest, Portland 97227, Oregon, United States.
Melissa G ChambersCenter for Structural Biology, Vanderbilt University, Nashville 37240, Tennessee, United States.
John KatsarasNeutron Scattering Division and Shull Wollan Center, Oak Ridge National Laboratory, Oak Ridge 37831, Tennessee, United States.
Markus W VoehlerCenter for Structural Biology and Department of Chemistry, Vanderbilt University, Nashville 37240, Tennessee, United States.
Brandon T RuotoloDepartment of Chemistry, University of Michigan, Ann Arbor 48109, Michigan, United States.ORCID 0000-0002-6084-2328
Daniel HusterInstitute for Medical Physics and Biophysics, Leipzig University, Leipzig 16-18, 04107, Germany.ORCID 0000-0002-3273-0943
Robert L McFeetersDepartment of Chemistry, University of Alabama, Huntsville 35899, Alabama, United States.
John E StraubDepartment of Chemistry, Boston University, Boston 02215, Massachusetts, United States.
Mu-Ping NiehPolymer Program, Department of Chemical & Biomolecular Engineering, and Department of Biomedical Engineering, University of Connecticut, Storrs 06269, Connecticut, United States.ORCID 0000-0003-4462-8716
Charles R SandersCenter for Structural Biology, Department of Biochemistry, and Department of Medicine, Vanderbilt University School of Medicine, Nashville 37240, Tennessee, United States.ORCID 0000-0003-2046-2862
Vanderbilt University · USUniversity of Michigan · USBoston University · USKaiser Permanente Center for Health Research · USLeipzig University · DEOak Ridge National Laboratory · USUniversity of Connecticut · USUniversity of Alabama in Huntsville · US
Funding
Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4MMOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9MFolding, Misfolding, and Function of PMP22R01NS095989 · NINDS · VANDERBILT UNIVERSITY · PI Bruce D Carter, CHARLES R SANDERS · 2016 to 2026
$4.6MRoles of Cholesterol and Membrane Nanodomains in the Amyloidogenic PathwayRF1AG056147 · NIA · VANDERBILT UNIVERSITY · PI KENWORTHY, ANNE K, SANDERS, CHARLES R · 2017 to 2017
$3.6MProbing the roles of membrane and cholesterol on Aβ biogenesis and prion protein interactionsR01GM107703 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI STRAUB, JOHN E., THIRUMALAI, DEVARAJAN · 2015 to 2022
$2.7MNew Structural Mass Spectrometry Tools Applied to the Mitochondrial Membrane ProtR01GM105942 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, RUOTOLO, BRANDON T · 2013 to 2016
$1.4MCholesterol and the Amyloid Precursor ProteinR01GM106672 · NIGMS · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2013 to 2016
$1.2MA Simultaneous SAXS/WAXS Detector System for Solving Biological StructuresS10OD012331 · OD · STATE UNIVERSITY NEW YORK STONY BROOK · PI ALLAIRE, MARC · 2012 to 2012
$1.1MConsole upgrades for biological NMR spectrometersS10RR025677 · NCRR · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2009 to 2009
$460kImpact of Cholesterol and Lipid Rafts on C99 Structure and ProcessingF31AG061984 · NIA · VANDERBILT UNIVERSITY · PI HUTCHISON, JAMES M · 2019 to 2020
$60kNCRR NIH HHS S10 RR025677NIA NIH HHS F31 AG061984NIA NIH HHS RF1 AG056147NIGMS NIH HHS P41 GM111244NIGMS NIH HHS R01 GM105942NIGMS NIH HHS R01 GM106672NIGMS NIH HHS R01 GM107703NIGMS NIH HHS T32 GM008320NIH HHS S10 OD012331NINDS NIH HHS R01 NS095989
Abstract
How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids and cholesterol. This gap is addressed by showing that
Indexed as
CholesterolCryoelectron MicroscopyHumansMembrane ProteinsSphingolipidsCholesterolMembrane ProteinsSphingolipids
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