Evidence map›Paper›PMID 32575805›Full record

ArticleNutrients2020

Mini Nutritional Assessment May Identify a Dual Pattern of Perturbed Plasma Amino Acids in Patients with Alzheimer's Disease: A Window to Metabolic and Physical Rehabilitation?

Roberto Aquilani, Alfredo Costa, Roberto Maestri, Matteo Cotta Ramusino, Antonia Pierobon, Maurizia Dossena, Sebastiano Bruno Solerte, Anna Maria Condino, Valeria Torlaschi, Paola Bini and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Roberto AquilaniDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Alfredo CostaCenter of Cognitive and Behavioral Disorders, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Roberto MaestriDepartment of Biomedical Engineering of the Montescano Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27040 Montescano (PV), Italy.
Matteo Cotta RamusinoCenter of Cognitive and Behavioral Disorders, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Antonia PierobonPsychology Unit of the Montescano Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27040 Montescano (PV), Italy.
Maurizia DossenaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Sebastiano Bruno SolerteDepartment of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Anna Maria CondinoDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Valeria TorlaschiPsychology Unit of the Montescano Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27040 Montescano (PV), Italy.
Paola BiniCenter of Cognitive and Behavioral Disorders, IRCCS Mondino Foundation, 27100 Pavia, Italy.
Mirella BoselliNeurorehabilitation Unit of the Montescano Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27040 Montescano (PV), Italy.
Mauro CeroniDepartment of Brain and Behavior, University of Pavia, 27100 Pavia, Italy.
Daniela BuonocoreDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Federica BoschiDepartment of Drug Sciences, University of Pavia, 27100 Pavia, Italy.
Mariella BruniMedical Laboratory Service of the Pavia Institute, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy.
Manuela VerriDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
University of Pavia · ITIstituti Clinici Scientifici Maugeri · ITFondazione Istituto Neurologico Nazionale Casimiro Mondino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conflicting results about alterations of plasma amino acid (AA) levels are reported in subjects with Alzheimer's disease (AD). The current study aimed to provide more homogeneous AA profiles and correlations between AAs and cognitive tests. Venous plasma AAs were measured in 54 fasting patients with AD (37 males, 17 females; 74.63 ± 8.03 yrs; 3.2 ± 1.9 yrs from symptom onset). Seventeen matched subjects without neurodegenerative symptoms (NNDS) served as a control group (C-NNDS). Patients were tested for short-term verbal memory and attention capacity and stratified for nutritional state (Mini Nutritional Assessment, MNA). Compared to C-NNDS, patients exhibited lower plasma levels of aspartic acid and taurine (

Indexed as

Nutritional StatusAgedAged, 80 and overAlzheimer DiseaseAmino AcidsAttentionFemaleHistidineHumansMaleMalnutritionMemoryMemory DisordersNutrition AssessmentSerineAmino AcidsHistidineSerineAlzheimer’s diseasecognitive testsnutritional stateplasma amino acids

Identifiers

PMID32575805
PMCPMC7353235
OpenAlexW3035884296

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.