Evidence map›Paper›PMID 32575793›Full record

ArticleInternational journal of molecular sciences2020

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using

Sze Yuan Ho, Yuet Ping Kwan, Beiying Qiu, Alison Tan, Hannah Louise Murray, Veluchamy Amutha Barathi, Nguan Soon Tan, Chui Ming Gemmy Cheung, Tien Yin Wong, Walter Wahli and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Sze Yuan HoLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, Singapore.
Yuet Ping KwanLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, Singapore.
Beiying QiuInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, Singapore.
Alison TanInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, Singapore.
Hannah Louise MurrayInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, Singapore.
Veluchamy Amutha BarathiSingapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore.
Nguan Soon TanLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, Singapore.ORCID 0000-0003-0136-7341
Chui Ming Gemmy CheungSingapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore.ORCID 0000-0003-3358-3516
Tien Yin WongSingapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore.
Walter WahliLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, Singapore.ORCID 0000-0002-5966-9089
Xiaomeng WangLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, Singapore.ORCID 0000-0002-1036-2764
Agency for Science, Technology and Research · SGNanyang Technological University · SGSingapore Eye Research Institute · SGNational University of Singapore · SG

Funding

National Medical Research Council NMRC/OFLCG/001/2017National Medical Research Council NMRC/OFLCG/004/2018
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in

Indexed as

AnimalsCells, CulturedChoroidal NeovascularizationDisease Models, AnimalHaploinsufficiencyHumansLasersMiceReceptors, Cytoplasmic and NuclearRetinal VesselsVascular RemodelingPpard protein, mouseReceptors, Cytoplasmic and Nuclearangiogenesisarteriovenous crossoverblood vessel remodelingpericytesPPARβ/δvessel caliber

Identifiers

PMID32575793
PMCPMC7353058
OpenAlexW3036367415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.