Evidence map›Paper›PMID 32575645›Full record

ArticleInternational journal of molecular sciences2020

Antibiotics Act with vB_AbaP_AGC01 Phage against

Bartłomiej Grygorcewicz, Marta Roszak, Piotr Golec, Daria Śleboda-Taront, Natalia Łubowska, Martyna Górska, Joanna Jursa-Kulesza, Rafał Rakoczy, Bartosz Wojciuk, Barbara Dołęgowska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Advances in phage therapy forFrontiers in microbiology · 2026
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  11. Article
  12. Isolation, characterization and therapeutic evaluation of phage HHU1 against K2Frontiers in cellular and infection microbiology · 2025
    Article
  13. Phage-antibiotic combinations againstFrontiers in microbiology · 2025
    Article
  14. Identification of multi-drug resistantFrontiers in microbiology · 2025
    Article
  15. Review
  16. Article
  17. Lytic Capsule-SpecificViruses · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Bartłomiej GrygorcewiczDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0002-0593-0069
Marta RoszakDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Piotr GolecDepartment of Molecular Virology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0001-7232-4440
Daria Śleboda-TarontDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Natalia ŁubowskaDepartment of Medical Microbiology, Faculty of Medicine, Medical University of Gdansk; Marii Skłodowskiej-Curie 3a, 80-210 Gdańsk, Poland.ORCID 0000-0002-3985-2572
Martyna GórskaDepartment of General Pathology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Joanna Jursa-KuleszaDepartment of Medical Microbiology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Rafał RakoczyInstitute of Chemical Engineering and Environmental Protection Process, Faculty of Chemical Engineering, West Pomeranian University of Technology, al. Piastów 42, 71-065 Szczecin, Poland.ORCID 0000-0002-5770-926X
Bartosz WojciukDepartment of Diagnostic Immunology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.ORCID 0000-0002-2990-0323
Barbara DołęgowskaDepartment of Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Pomeranian Medical University · PLUczelnia Warszawska im. Marii Skłodowskiej-Curie · PLUniversity of Warsaw · PLWest Pomeranian University of Technology in Szczecin · PL

Funding

Ministerstwo Nauki i Szkolnictwa Wyższego 002/RID/2018/19Narodowe Centrum Nauki 2018/29/N/ST8/01043Narodowe Centrum Nauki 2018/31/B/ST8/03170
6 · The paper itself

Abstract

Increasing multidrug resistance has led to renewed interest in phage-based therapy. A combination of the bacteriophages and antibiotics presents a promising approach enhancing the phage therapy effectiveness. First, phage candidates for therapy should be deeply characterized. Here we characterize the bacteriophage vB_AbaP_AGC01 that poses antibacterial activity against clinical Acinetobacter baumannii strains. Moreover, besides genomic and phenotypic analysis our study aims to analyze phage-antibiotic combination effectiveness with the use of ex vivo and in vivo models. The phage AGC01 efficiently adsorbs to A. baumannii cells and possesses a bacteriolytic lifecycle resulting in high production of progeny phages (317 ± 20 PFU × cell

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnimalsAnti-Bacterial AgentsBacteriolysisBacteriophagesCiprofloxacinCombined Modality TherapyDisease Models, AnimalGenome, ViralHot TemperatureHumansLepidopteraMeropenemPhage TherapyPhenotypeAnti-Bacterial AgentsCiprofloxacinMeropenemAcinetobacter baumanniiantibiotics resistancebacteriophagesblood infectionGalleria mellonella

Identifiers

PMID32575645
PMCPMC7352404
OpenAlexW3036921859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.