Evidence map›Paper›PMID 32575561›Full record

ReviewNutrients2020

Effect of Gluten-Free Diet on Gut Microbiota Composition in Patients with Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity.

Giacomo Caio, Lisa Lungaro, Nicola Segata, Matteo Guarino, Giorgio Zoli, Umberto Volta, Roberto De Giorgio

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.

  1. Pooled it
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  5. Novel probiotic preparation withMicrobiology spectrum · 2024
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Giacomo CaioDepartment of Morphology, Surgery and Experimental Medicine, St. Anna University Hospital, University of Ferrara, 44124 Cona, Italy.
Lisa LungaroDepartment of Morphology, Surgery and Experimental Medicine, SS. Annunziata Hospital, University of Ferrara, 44042 Cento, Italy.
Nicola SegataDepartment of Integrated and Computational Cell Biology (CIBIO), University of Trento, 38122 Trento, Italy.ORCID 0000-0002-1583-5794
Matteo GuarinoDepartment of Morphology, Surgery and Experimental Medicine, St. Anna University Hospital, University of Ferrara, 44124 Cona, Italy.ORCID 0000-0001-5841-8555
Giorgio ZoliDepartment of Morphology, Surgery and Experimental Medicine, SS. Annunziata Hospital, University of Ferrara, 44042 Cento, Italy.
Umberto VoltaDepartment of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
Roberto De GiorgioDepartment of Morphology, Surgery and Experimental Medicine, St. Anna University Hospital, University of Ferrara, 44124 Cona, Italy.ORCID 0000-0003-0867-5873
University of Ferrara · ITHarvard University · USUniversity of Bologna · ITUniversity of Trento · IT

Funding

Ministero della Salute RF16MINT
6 · The paper itself

Abstract

Celiac disease (CD) and non-celiac gluten/wheat sensitivity (NCG/WS) are the two most frequent conditions belonging to gluten-related disorders (GRDs). Both these diseases are triggered and worsened by gluten proteins ingestion, although other components, such as amylase/trypsin inhibitors (ATI) and fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), seem to be involved in the NCG/WS onset. Therefore, the only effective treatment to date is the long-life adherence to a strictly gluten-free diet. Recently, increasing attention has been paid to the intestinal barrier, a dynamic system comprising various components, which regulate the delicate crosstalk between metabolic, motor, neuroendocrine and immunological functions. Among the elements characterizing the intestinal barrier, the microbiota plays a key role, modulating the gut integrity maintenance, the immune response and the inflammation process, linked to the CD and NCG/WS outbreak. This narrative review addresses the most recent findings on the gut microbiota modulation induced by the gluten-free diet (GFD) in healthy, CD and NCG/WS patients.

Indexed as

Celiac DiseaseDiet, Gluten-FreeGastrointestinal MicrobiomeGlutensHumansWheat HypersensitivityGlutensceliac diseasegluten-free dietgluten related disordersgut dysbiosisleaky gutmicrobiomemicrobiotanon-celiac gluten/wheat sensitivity

Identifiers

PMID32575561
PMCPMC7353361
OpenAlexW3036947443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.