Evidence map›Paper›PMID 32575479›Full record

ArticleInternational journal of molecular sciences2020

Agnieszka Gunia-Krzyżak, Ewa Żesławska, Karolina Słoczyńska, Dorota Żelaszczyk, Aleksandra Sowa, Paulina Koczurkiewicz-Adamczyk, Justyna Popiół, Wojciech Nitek, Elżbieta Pękala, Henryk Marona

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Agnieszka Gunia-KrzyżakJagiellonian University Medical College, Faculty of Pharmacy, Chair of Organic Chemistry, Department of Bioorganic Chemistry, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0003-4162-4760
Ewa ŻesławskaPedagogical University, Institute of Biology, Podchorążych 2, 30-084 Kraków, Poland.ORCID 0000-0003-1946-9370
Karolina SłoczyńskaJagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0002-7366-2676
Dorota ŻelaszczykJagiellonian University Medical College, Faculty of Pharmacy, Chair of Organic Chemistry, Department of Bioorganic Chemistry, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0001-7103-5292
Aleksandra SowaJagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Paulina Koczurkiewicz-AdamczykJagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Justyna PopiółJagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0002-9825-4302
Wojciech NitekJagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland.
Elżbieta PękalaJagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0002-1260-4253
Henryk MaronaJagiellonian University Medical College, Faculty of Pharmacy, Chair of Organic Chemistry, Department of Bioorganic Chemistry, Medyczna 9, 30-688 Kraków, Poland.
Jagiellonian University · PLUniwersytet Komisji Edukacji Narodowej w Krakowie · PL

Funding

Uniwersytet Jagielloński Collegium Medicum K/DSC/004292Uniwersytet Jagielloński Collegium Medicum K/ZDS/007882Uniwersytet Jagielloński Collegium Medicum N42/DBS/000101
6 · The paper itself

Abstract

Epilepsy is one of the most frequent neurological disorders affecting about 1% of the world's human population. Despite availability of multiple treatment options including antiseizure drugs, it is estimated that about 30% of seizures still remain resistant to pharmacotherapy. Searching for new antiseizure and antiepileptic agents constitutes an important issue within modern medicinal chemistry. Cinnamamide derivatives were identified in preclinical as well as clinical studies as important drug candidates for the treatment of epilepsy. The cinnamamide derivative presented here:

Indexed as

AnimalsAnticonvulsantsCell LineCinnamatesCrystallographyDisease Models, AnimalEpilepsyHep G2 CellsHumansInjections, IntraperitonealMaleMiceMolecular StructureRatsSeizuresAnticonvulsantsCinnamatesanticonvulsantantiseizure, cinnamamide derivativescrystallographydrug developmentepilepsypreclinical safety evaluation

Identifiers

PMID32575479
PMCPMC7352759
OpenAlexW3035802855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.