Evidence map›Paper›PMID 32575429›Full record

ReviewCells2020

Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer.

Alessia Cimadamore, Gaetano Aurilio, Franco Nolé, Francesco Massari, Marina Scarpelli, Matteo Santoni, Antonio Lopez-Beltran, Liang Cheng, Rodolfo Montironi

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Alessia CimadamoreSection of Pathological Anatomy, Faculty of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60126 Ancona, Italy.ORCID 0000-0001-5981-3514
Gaetano AurilioDepartment of Medical Oncology, Division of Urogenital and Head and Neck Tumours, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Franco NoléDepartment of Medical Oncology, Division of Urogenital and Head and Neck Tumours, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
Francesco MassariDivision of Oncology, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy.ORCID 0000-0001-6476-6871
Marina ScarpelliSection of Pathological Anatomy, Faculty of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60126 Ancona, Italy.
Matteo SantoniOncology Unit, Macerata Hospital, 62100 Macerata, Italy.
Antonio Lopez-BeltranDepartment of Surgery, Medical School, Cordoba University, 14004 Cordoba, Spain.ORCID 0000-0003-3161-8164
Liang ChengDepartment of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 462020, USA.ORCID 0000-0001-6049-5293
Rodolfo MontironiSection of Pathological Anatomy, Faculty of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60126 Ancona, Italy.ORCID 0000-0003-3938-610X
Marche Polytechnic University · ITEuropean Institute of Oncology · ITIndiana University Indianapolis · USIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITOspedale di MacerataUniversity of Córdoba · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current developments in the treatment of genitourinary tumors underline the unmet clinical need for biomarkers to improve decision-making in a challenging clinical setting. The detection of circulating tumor cells (CTCs) has become one of the most exciting and important new approaches to identifying biomarkers at different stages of disease in a non-invasive way. Potential applications of CTCs include monitoring treatment efficacy and early detection of progression, selecting tailored therapies, as well as saving treatment costs. However, despite the promising implementation of CTCs in a clinical scenario, the isolation and characterization of these cells for molecular studies remain expensive with contemporary platforms, and significant technical challenges still need to be overcome. This updated, critical review focuses on the state of CTCs in patients with genitourinary tumor with focus on prostate cancer, discussing technical issues, main clinical results and hypothesizing potential future perspectives in clinical scenarios.

Indexed as

Biomarkers, TumorCell CountHumansMaleNeoplastic Cells, CirculatingProstatic NeoplasmsUrinary Bladder NeoplasmsUrogenital NeoplasmsBiomarkers, Tumorcirculating tumor cellsgenitourinary cancersimmune checkpoint inhibitorsliquid biopsyprecision oncology

Identifiers

PMID32575429
PMCPMC7348874
OpenAlexW3035788894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.