ReviewBrain sciences2020
Functional Aspects of Hypothalamic Asymmetry.
Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Hypothalamus volumes and mental health in children and adolescents.Frontiers in neuroscience · 2026Article
- Article
- Hypothalamic subunit atrophy and glymphatic dysfunction in idiopathic hypogonadotropic hypogonadism: associations with cognitive impairment.BMC medical imaging · 2025Article
- Changes in hypothalamic subunits volume and their association with metabolic parameters and gastrointestinal appetite-regulating hormones following bariatric surgery.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- High-resolution segmentations of the hypothalamus and its subregions for training of segmentation models.Scientific data · 2024Article
- Article
- Review
- Assessment of Accuracy of Spatial Object Localization by Means of Mono and Stereo Modes of Visual-to-Auditory Sensory Substitution in People with Visual Impairments (a Pilot Study).Sovremennye tekhnologii v meditsine · 2024Article
- Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents.International journal of molecular sciences · 2023Article
- Advancements in the Management of Endocrine System Disorders and Arrhythmias: A Comprehensive Narrative Review.Cureus · 2023Review
- Hypothalamus volumes in adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): impact of self-reported fatigue and illness duration.Brain structure & function · 2023Article
- Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma.Translational psychiatry · 2023Article
- The left-right side-specific endocrine signaling in the effects of brain lesions: questioning of the neurological dogma.Cellular and molecular life sciences : CMLS · 2022Review
- Hypothalamic effective connectivity at rest is associated with body weight and energy homeostasis.Network neuroscience (Cambridge, Mass.) · 2022Article
- Lower hypothalamus subunit volumes link with impaired long-term body weight gain after preterm birth.Frontiers in endocrinology · 2022Article
- Article
- Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis.Frontiers in endocrinology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric specialization correlates with phylogeny supporting intellectual evolution by providing an ergonomic way of brain processing. The more complex the task, the higher are the benefits of the functional lateralization (all higher functions show some degree of lateralized task sharing). Functional asymmetry has been broadly studied in several brain areas with mirrored halves, such as the telencephalon, hippocampus, etc. Despite its paired structure, the hypothalamus has been generally considered as a functionally unpaired unit, nonetheless the regulation of a vast number of strongly interrelated homeostatic processes are attributed to this relatively small brain region. In this review, we collected all available knowledge supporting the hypothesis that a functional lateralization of the hypothalamus exists. We collected and discussed findings from previous studies that have demonstrated lateralized hypothalamic control of the reproductive functions and energy expenditure. Also, sporadic data claims the existence of a partial functional asymmetry in the regulation of the circadian rhythm, body temperature and circulatory functions. This hitherto neglected data highlights the likely high-level ergonomics provided by such functional asymmetry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.