ReviewCells2020
Neutrophil Extracellular Traps in Periodontitis.
Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Periodontitis as an independent risk factor for cardiovascular disease: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Association between smoking cessation and periodontitis progression: a systematic review and meta-analysis of prospective observational studies.Frontiers in oral health · 2026Pooled it
- IL-23/IL-17 axis levels in gingival crevicular fluid of subjects with periodontal disease: a systematic review.BMC oral health · 2024Pooled it
- Periodontal and Peri-Implant Status Among Users of Different Inhaled Tobacco and Nicotine Products: A Systematic Review.Dentistry journal · 2026Review
- Neutrophil Extracellular Traps Promote the Formation of Canine Dental Calculus.Veterinary sciences · 2026Article
- Gingival Crevicular Fluid Proteomic Shift: From Gingivitis to Periodontitis.International dental journal · 2026Article
- The Effect of Personalized Oral Health Education on Oral Hygiene Behavior and Periodontal Health: A Meta-Analysis and Systematic Review.International journal of dentistry · 2026Review
- Immunological cross-talk between periodontitis and systemic lupus erythematosus: the role of T-B cell dysregulation in the shared pathogenic network.Frontiers in immunology · 2026Review
- From Oxidised LDL to Potential Novel Applications in Gingival Crevicular Fluid Analysis.International journal of molecular sciences · 2025Review
- Association Between Periodontal Disease and Blood Biomarkers in U.S. Adults: A Cross-Sectional Study.Biomedicines · 2025Article
- Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease.Microorganisms · 2025Review
- Greater bone regeneration required for implants following periodontal extraction: a retrospective cross-sectional study.BMC oral health · 2025Observational
- The impact of aging on neutrophil functions and the contribution to periodontitis.International journal of oral science · 2025Review
- Impact of Protein Citrullination by Periodontal Pathobionts on Oral and Systemic Health: A Systematic Review of Preclinical and Clinical Studies.Journal of clinical medicine · 2024Review
- Periodontal disease: A systemic condition.Periodontology 2000 · 2024Review
- Local Drug Delivery Systems as Novel Approach for Controlling NETosis in Periodontitis.Pharmaceutics · 2024Review
- Neutrophil Extracellular Traps: An Emerging Therapeutic Target to Improve Infectious Disease Outcomes.The Journal of infectious diseases · 2024Review
- Independent and combined effects of smoking, drinking and depression on periodontal disease.BMC oral health · 2024Article
- Neutrophils and neutrophil extracellular traps in oral health and disease.Experimental & molecular medicine · 2024Review
- Neutrophils in Inflammatory Bone Diseases.Current osteoporosis reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released into extracellular space following neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and drugs. Neutrophils can remain functional after NET formation and are important for periodontal homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state between the gingival microbiome and the immune response of the host. The pathogenesis of periodontitis includes an immune-inflammatory component in which impaired NET formation and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the destruction of gingival tissue. In this review, we summarize the current knowledge about the role of NETs in the pathogenesis of periodontitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.