Observational studyAging2020
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan.
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations.Mitochondrion · 2021Pooled it
- Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.Scientific reports · 2025Trial
- An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL.Immunity & ageing : I & A · 2026Article
- Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.Research square · 2026Article
- Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.bioRxiv : the preprint server for biology · 2026Article
- Humanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.Biochemistry and biophysics reports · 2026Article
- Mitochondria-derived peptides in liver disease: Emerging regulators of hepatic metabolism and therapeutic targets.Hepatology communications · 2026Review
- Article
- Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.Journal of the American Heart Association · 2025Article
- Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer.Neoplasia (New York, N.Y.) · 2025Article
- Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.Clinical and experimental medicine · 2025Article
- Are Hippocampal Hypoperfusion and ATP Depletion Prime Movers in the Genesis of Alzheimer's Disease? A Review of Recent Pertinent Observations from Molecular Biology.International journal of molecular sciences · 2025Review
- Eukaryotic Microproteins.Annual review of biochemistry · 2025Review
- Current Perspectives on Functional Involvement of Micropeptides in Virus-Host Interactions.International journal of molecular sciences · 2025Review
- Mitochondrial-derived microproteins: from discovery to function.Trends in genetics : TIG · 2025Review
- A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.Protein and peptide letters · 2025Review
- Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.Frontiers in nutrition · 2025Article
- Gene Expression Profile of Gm20594 and Hapln1 in Mouse Cardiac Muscle Exposed to Microgravity and Space-like Chronic Low-Dose Radiation.microPublication biology · 2025Article
- Exercise Improves Cardiac Dysfunction in D-Galactose-Treated Rats by Regulation of IGF-1-Humanin Pathway.Journal of aging research · 2025Article
- [Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.Scientific reports · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 2 countries.
Kelvin YenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Hemal H MehtaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Su-Jeong KimLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
YanHe LueDepartment of Medicine, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
James HoangDepartment of Medicine, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Noel GuerreroLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Jenna PortLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Qiuli BiLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Gerardo NavarreteLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Sebastian BrandhorstLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Kaitlyn Noel LewisDepartment of Physiology, The Barshop Institute, University of Texas Health at San Antonio, TX 78229, USA.
Junxiang WanLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Ronald SwerdloffDepartment of Medicine, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Julie A MattisonTranslational Gerontology Branch, National Institute on Aging, Dickerson, MD 20892, USA.
Rochelle BuffensteinDepartment of Physiology, The Barshop Institute, University of Texas Health at San Antonio, TX 78229, USA.
Carrie V BretonDepartment of Preventive Medicine, Keck School of Medicine, USC, Los Angeles, CA 90089, USA.
Christina WangDepartment of Medicine, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Valter LongoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Gil AtzmonDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Douglas WallaceCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Department of Pediatrics, Division of Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nir BarzilaiDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
University of Southern California · USUCLA Medical Center · USAlbert Einstein College of Medicine · USThe University of Texas Health Science Center at San Antonio · USChildren's Hospital of Philadelphia · USHarbor–UCLA Medical Center · USKeck Hospital of USC · USNational Institute on Aging · US
Funding
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MRole of the Mitochondrial Peptide Humanin in Regulating Aging and HealthspanP01AG055369 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LONGO, VALTER D. · 2018 to 2023
$12.4MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8MROLE OF NUTRIENTS IN AGE-RELATED INSULIN RESISTANCEP01AG021654 · NIA · YESHIVA UNIVERSITY · PI BARZILAI, NIR J · 2003 to 2007
$10.6MThe Role of the Glucose-regulated Protein GRP78/BiP in Stress Resistance and AginP01AG034906 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MITCHELL, JAMES R. · 2011 to 2016
$9.3MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MEthnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and DementiaR01AG068405 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS, CRIMMINS, EILEEN M · 2020 to 2024
$3.6MHumanin is an AD resilience factor through its interaction with APOE4RF1AG061834 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS · 2018 to 2018
$3.3MEpigenetic Profiling in Healthy Aging and Exceptional LongevityR01AG042188 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ATZMON, GIL, BARZILAI, NIR J · 2011 to 2015
$2.0MA family of novel mitochondrially-encoded peptides and their role in agingR01AG034430 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS · 2009 to 2012
$1.2MMitochondrial epigenetics, traffic-related pollution and neonatal healthR21ES025870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2015 to 2016
$468kNIA NIH HHS P01 AG021654NIA NIH HHS P01 AG034906NIA NIH HHS P01 AG055369NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG034430NIA NIH HHS R01 AG042188NIA NIH HHS R01 AG068405NIA NIH HHS RF1 AG061834NIDDK NIH HHS P30 DK020541NIEHS NIH HHS R21 ES025870NIH HHS P40 OD010440
Abstract
Humanin is a member of a new family of peptides that are encoded by short open reading frames within the mitochondrial genome. It is conserved in animals and is both neuroprotective and cytoprotective. Here we report that in
Indexed as
AdultAged, 80 and overAlzheimer DiseaseAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCase-Control StudiesChildCohort StudiesDNA, MitochondrialFemaleForkhead Transcription FactorsGene DosageHumansInfant, NewbornCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDNA, MitochondrialForkhead Transcription FactorshumaninIntracellular Signaling Peptides and Proteinsaginghumaninmitochondriapeptides
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.