ArticleNeuroImage2020
Personality and local brain structure: Their shared genetic basis and reproducibility.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.Molecular psychiatry · 2026Article
- Leveraging normative personality data and machine learning to examine the brain structure correlates of obsessive-compulsive personality disorder traits.Journal of psychopathology and clinical science · 2024Article
- Directional Spatial and Spectral Attention Network (DSSA Net) for EEG-based emotion recognition.Frontiers in neurorobotics · 2024Article
- Neurocircuitry of Personality Traits and Intent in Decision-Making.Behavioral sciences (Basel, Switzerland) · 2023Review
- Premorbid Personality Traits as Risk Factors for Behavioral Addictions: A Systematic Review of a Vulnerability Hypothesis.Children (Basel, Switzerland) · 2023Review
- Trust toward humans and trust toward artificial intelligence are not associated: Initial insights from self-report and neurostructural brain imaging.Personality neuroscience · 2023Article
- Linking interindividual variability in brain structure to behaviour.Nature reviews. Neuroscience · 2022Review
- The association between local brain structure and disgust propensity.Scientific reports · 2022Article
- Personality Neuroscience: An Emerging Field with Bright Prospects.Personality science · 2022Article
- "Nothing to see here": No structural brain differences as a function of thePersonality neuroscience · 2022Review
- Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex.NeuroImage · 2021Article
- Network Controllability in Transmodal Cortex Predicts Positive Psychosis Spectrum Symptoms.Biological psychiatry · 2021Article
- Transdiagnostic dimensions of psychopathology explain individuals' unique deviations from normative neurodevelopment in brain structure.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Local cortical architecture is highly heritable and distinct genes are associated with specific cortical regions. Total surface area has been shown to be genetically correlated with complex cognitive capacities, suggesting cortical brain structure is a viable endophenotype linking genes to behavior. However, to what extend local brain structure has a genetic association with cognitive and emotional functioning is incompletely understood. Here, we study the genetic correlation between personality traits and local cortical structure in a large-scale twin sample (Human Connectome Project, n = 1102, 22-37y) and we evaluated whether observed associations reflect generalizable relationships between personality and local brain structure two independent age-matched samples (Brain Genomics Superstructure Project: n = 925, age = 19-35y, enhanced Nathan Kline Institute dataset: n = 209, age: 19-39y). We found a genetic overlap between personality traits and local cortical structure in 10 of 18 observed phenotypic associations in predominantly frontal cortices. However, we only observed evidence in favor of replication for the negative association between surface area in medial prefrontal cortex and Neuroticism in both replication samples. Quantitative functional decoding indicated this region is implicated in emotional and socio-cognitive functional processes. In sum, our observations suggest that associations between local brain structure and personality are, in part, under genetic control. However, associations are weak and only the relation between frontal surface area and Neuroticism was consistently observed across three independent samples of young adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.