Evidence map›Paper›PMID 32574559›Full record

ArticleNeuron2020

Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals.

Lief E Fenno, Charu Ramakrishnan, Yoon Seok Kim, Kathryn E Evans, Maisie Lo, Sam Vesuna, Masatoshi Inoue, Kathy Y M Cheung, Elle Yuen, Nandini Pichamoorthy and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 176 citations in OpenAlex.

  1. Article
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  6. Intrinsic space-time couplings governing multi-scale cortical dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026
    Article
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  15. Review
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  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lief E FennoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Yoon Seok KimDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Kathryn E EvansDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Maisie LoDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Sam VesunaDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Masatoshi InoueDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Kathy Y M CheungDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Elle YuenDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Nandini PichamoorthyDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Alice S O HongDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Karl DeisserothDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: deissero@stanford.edu.
Stanford University · USHoward Hughes Medical Institute · US

Funding

OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALESR01MH086373 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2010 to 2025
$9.1M
Howard Hughes Medical InstituteNIMH NIH HHS R01 MH086373
6 · The paper itself

Abstract

The resolution and dimensionality with which biologists can characterize cell types have expanded dramatically in recent years, and intersectional consideration of such features (e.g., multiple gene expression and anatomical parameters) is increasingly understood to be essential. At the same time, genetically targeted technology for writing in and reading out activity patterns for cells in living organisms has enabled causal investigation in physiology and behavior; however, cell-type-specific delivery of these tools (including microbial opsins for optogenetics and genetically encoded Ca

Indexed as

Genetic TechniquesNeuronsOptogeneticsAnimalsDependovirusGenetic VectorsHEK293 CellsHumanscalcium imagingchannelrhodopsinCreFlpfluorophoresintersectionaloptogeneticsrecombinasetargetingVCre

Identifiers

PMID32574559
PMCPMC7687746
OpenAlexW3036691738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.