Evidence map›Paper›PMID 32574550›Full record

ArticleOpen biology2020

An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease.

Sandra Anne Banack, Rachael Anne Dunlop, Paul Alan Cox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sandra Anne BanackBrain Chemistry Labs, Institute for Ethnomedicine, PO Box 3464, Jackson, WY 83001, USA.
Rachael Anne DunlopBrain Chemistry Labs, Institute for Ethnomedicine, PO Box 3464, Jackson, WY 83001, USA.
Paul Alan CoxBrain Chemistry Labs, Institute for Ethnomedicine, PO Box 3464, Jackson, WY 83001, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We hypothesized that neural-enriched extracellular vesicles could provide microRNA (miRNA) fingerprints with unequivocal signatures of neurodegeneration. Using blood plasma from ALS/MND patients and controls, we extracted neural-enriched extracellular vesicle fractions and conducted next-generation sequencing and qPCR of miRNA components of the transcriptome. We here report eight miRNA sequences which significantly distinguish ALS/MND patients from controls in a replicated experiment using a second cohort of patients and controls. miRNA sequences from patient blood samples using neural-enriched extracellular vesicles may yield unique insights into mechanisms of neurodegeneration and assist in early diagnosis of ALS/MND.

Indexed as

Amyotrophic Lateral SclerosisDNA FingerprintingExtracellular VesiclesFemaleGene Expression RegulationGenetic MarkersHigh-Throughput Nucleotide SequencingHumansMaleMicroRNAsMotor Neuron DiseasePilot ProjectsSequence Analysis, RNAGenetic MarkersMicroRNAsALS/MNDbiomarkersexosomesmiRNAneurodegeneration

Identifiers

PMID32574550
PMCPMC7333885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.