ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020
Seasonally variant gene expression in full-term human placenta.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Maternal sleep deprivation and developmental programming of brain aging trajectories in offspring.Biogerontology · 2026Review
- Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk.Environmental epigenetics · 2026Article
- Characteristics of objectively-measured naturalistic light exposure patterns in U.S. adults: A cross-sectional analysis of two cohorts.The Science of the total environment · 2025Article
- LncRNA MIR210HG promotes the proliferation of colon cancer cells by inhibiting ferroptosis through binding to PCBP1.Scientific reports · 2025Article
- Placental transcriptome variation associated with season, location, and urinary prenatal pyrethroid metabolites of Thai farm-working women.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Brain Dopamine-Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects.International journal of molecular sciences · 2023Review
- Placental Gene Transcript Proportions are Altered in the Presence ofFrontiers in genetics · 2022Article
- A Comprehensive Assessment of Associations between Prenatal Phthalate Exposure and the Placental Transcriptomic Landscape.Environmental health perspectives · 2021Article
- Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.Frontiers in genetics · 2021Review
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Seasonal exposures influence human health and development. The placenta, as a mediator of the maternal and fetal systems and a regulator of development, is an ideal tissue to understand the biological pathways underlying relationships between season of birth and later life health outcomes. Here, we conducted a differential expression (DE) analysis of season of birth in full-term human placental tissue to evaluate whether the placenta may be influenced by seasonal cues. Of the analyzed transcripts, 583 displayed DE between summer and winter births (False Discovery Rate [FDR] q < .05); among these, BHLHE40, MIR210HG, and HILPDA had increased expression among winter births (Bonferroni P < .05). Enrichment analyses of the seasonally variant genes between summer and winter births indicated overrepresentation of transcription factors HIF1A, VDR, and CLOCK, among others, and of GO term pathways related to ribosomal activity and infection. Additionally, a cosinor analysis found rhythmic expression for approximately 11.9% of all 17 664 analyzed placental transcripts. These results suggest that the placenta responds to seasonal cues and add to the growing body of evidence that the placenta acts as a peripheral clock, which may provide a molecular explanation for the extensive associations between season of birth and health outcomes.
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