ArticlePLoS pathogens2020
A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 86 citations in OpenAlex.
- Lysin Motif Effectors Facilitate the Endophytic Colonization of Wheat by Sclerotinia sclerotiorum via Modulating Plant Immunity.Molecular plant pathology · 2026Article
- Oxidative stress impacts carbon metabolism and induces upregulation of redox enzymes andsmall secreted proteins in the wood-decay fungus.Fungal biology and biotechnology · 2026Article
- The glycosylated root-knot nematode effector Minc10750 suppresses plant immunity by destabilizing host chitinases.The New phytologist · 2026Article
- Protein QID74 protects the cell wall ofmBio · 2026Article
- Advanced Research on LysM Domain-Containing Proteins: Functional Mechanisms and Roles in Pathogenicity of Plant Fungi.International journal of molecular sciences · 2026Review
- Plant cell walls as a key driver of plant-pathogen coevolution.FEMS microbiology reviews · 2026Review
- Oligosaccharide elicitors in plant immunity: Molecular mechanisms and disease resistance strategies.Plant communications · 2025Review
- Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection.PLoS pathogens · 2025Article
- Structure-guided insights into the biology of fungal effectors.The New phytologist · 2025Review
- Genome-wide characterization of effector proteins in Fusarium zanthoxyli and their effects on plant's innate immunity responses.BMC plant biology · 2025Article
- Linear β-1,2-glucans trigger immune hallmarks and enhance disease resistance in plants.Journal of experimental botany · 2024Article
- An array of Zymoseptoria tritici effectors suppress plant immune responses.Molecular plant pathology · 2024Article
- Histone MethyltransferaseJournal of fungi (Basel, Switzerland) · 2024Article
- Article
- Small secreted effector protein from Fusarium sacchari suppresses host immune response by inhibiting ScPi21-induced cell death.Molecular plant pathology · 2024Article
- Article
- Deacetylation of chitin oligomers by Fusarium graminearum polysaccharide deacetylase suppresses plant immunity.Molecular plant pathology · 2023Article
- Article
- Revealing the Control Mechanisms of pH on the Solution Properties of Chitin via Single-Molecule Studies.Molecules (Basel, Switzerland) · 2023Article
- Structural and functional analysis of the cerato-platanin-like protein Cpl1 suggests diverging functions in smut fungi.Molecular plant pathology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants trigger immune responses upon recognition of fungal cell wall chitin, followed by the release of various antimicrobials, including chitinase enzymes that hydrolyze chitin. In turn, many fungal pathogens secrete LysM effectors that prevent chitin recognition by the host through scavenging of chitin oligomers. We previously showed that intrachain LysM dimerization of the Cladosporium fulvum effector Ecp6 confers an ultrahigh-affinity binding groove that competitively sequesters chitin oligomers from host immune receptors. Additionally, particular LysM effectors are found to protect fungal hyphae against chitinase hydrolysis during host colonization. However, the molecular basis for the protection of fungal cell walls against hydrolysis remained unclear. Here, we determined a crystal structure of the single LysM domain-containing effector Mg1LysM of the wheat pathogen Zymoseptoria tritici and reveal that Mg1LysM is involved in the formation of two kinds of dimers; a chitin-dependent dimer as well as a chitin-independent homodimer. In this manner, Mg1LysM gains the capacity to form a supramolecular structure by chitin-induced oligomerization of chitin-independent Mg1LysM homodimers, a property that confers protection to fungal cell walls against host chitinases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.