Evidence map›Paper›PMID 32574169›Full record

ArticlePloS one2020

The profile of lipid metabolites in urine of marmoset wasting syndrome.

Arisa Yamazaki, Tatsuro Nakamura, Takako Miyabe-Nishiwaki, Akihiro Hirata, Rikako Inoue, Koji Kobayashi, Yusuke Miyazaki, Yuta Hamasaki, Akiyo Ishigami, Nanae Nagata and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Arisa YamazakiDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Tatsuro NakamuraDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Takako Miyabe-NishiwakiDepartment of Primate Research Institute, Kyoto University, Aichi, Japan.
Akihiro HirataDepartment of Animal Experiment, Life Science Research Center, Gifu University, Gifu, Japan.
Rikako InoueDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Koji KobayashiDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Yusuke MiyazakiDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Yuta HamasakiDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Akiyo IshigamiDepartment of Primate Research Institute, Kyoto University, Aichi, Japan.
Nanae NagataDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Akihisa KanekoDepartment of Primate Research Institute, Kyoto University, Aichi, Japan.
Makoto KoizumiDepartment of Laboratory Animal Facilities, The Jikei University School of Medicine, Tokyo, Japan.
Hiroki OhtaDepartment of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Hirotaka James OkanoDepartment of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Takahisa MurataDepartment of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-3328-0796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marmoset wasting syndrome (MWS) is clinically characterized by progressive weight loss. Although morbidity and mortality of MWS are relatively high in captive marmosets, its causes remain unknown. Lipid mediators are bioactive metabolites which are produced from polyunsaturated fatty acids, such as arachidonic acid (AA) and eicosapentaenoic acid. These lipid metabolites regulate a wide range of inflammatory responses and they are excreted into the urine. As urinary lipid profiles reflect systemic inflammatory conditions, we comprehensively measured the levels of 141 types of lipid metabolites in the urines obtained from healthy common marmoset (Callithrix jacchus) (N = 7) or marmosets with MWS (N = 7). We found that 41 types of metabolites were detected in all urine samples of both groups. Among them, AA-derived metabolites accounted for 63% (26/41 types) of all detected metabolites. Notably, the levels of AA-derived prostaglandin (PG) E2, PGF2α, thromboxane (TX) B2 and F2-isoprostanes significantly increased in the urine samples of marmosets with MWS. In this study, we found some urinary lipid metabolites which may be involved in the development of MWS. Although the cause of MWS remains unclear, our findings may provide some insight into understanding the mechanisms of development of MWS.

Indexed as

MetabolomeAnimalsBody WeightCallithrixFatty Acids, UnsaturatedLipidsMetabolic Networks and PathwaysMonkey DiseasesOxidation-ReductionWasting SyndromeFatty Acids, UnsaturatedLipids

Identifiers

PMID32574169
PMCPMC7310677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.