Evidence map›Paper›PMID 32574033›Full record

ArticleACS nano2020

Acoustofluidic Scanning Nanoscope with High Resolution and Large Field of View.

Geonsoo Jin, Hunter Bachman, Ty Downing Naquin, Joseph Rufo, Serena Hou, Zhenhua Tian, Chenglong Zhao, Tony Jun Huang

Abstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Correlative AFM and Scanning Microlens Microscopy for Time-Efficient Multiscale Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Geonsoo JinDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.ORCID http://orcid.org/0000-0003-4765-4864
Hunter BachmanDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.ORCID http://orcid.org/0000-0002-2356-5392
Ty Downing NaquinDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.
Joseph RufoDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.
Serena HouDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.
Zhenhua TianDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.
Chenglong ZhaoDepartment of Physics, University of Dayton, 300 College Park, Dayton, Ohio 45469, United States.
Tony Jun HuangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708, United States.ORCID http://orcid.org/0000-0003-1205-3313

Funding

Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA BiomarkersR01GM135486 · NIGMS · DUKE UNIVERSITY · PI VO-DINH, TUAN · 2020 to 2023
$1.8M
Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platformR33CA223908 · NCI · NORTHEASTERN UNIVERSITY · PI EVENS, ANDREW M, HUANG, TONY JUN · 2018 to 2020
$1.2M
An integrated acoustofluidic droplet-sorting platform for classification of lymphocyte activity and functional phenotyping at single cell levelR01GM127714 · NIGMS · NORTHEASTERN UNIVERSITY · PI KONRY, TANIA TALI · 2018 to 2021
$1.2M
Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and BiofluidsUG3TR002978 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AN, JI YEONG, GALL, KENNETH A · 2019 to 2020
$823k
An acoustofluidic device for diagnosing preclinical Alzheimer's diseaseR43AG063643 · NIA · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2019 to 2019
$225k
NCATS NIH HHS UG3 TR002978NCI NIH HHS R33 CA223908NIA NIH HHS R43 AG063643NIGMS NIH HHS R01 GM127714NIGMS NIH HHS R01 GM132603NIGMS NIH HHS R01 GM135486
6 · The paper itself

Abstract

Optical imaging with nanoscale resolution and a large field of view is highly desirable in many research areas. Unfortunately, it is challenging to achieve these two features simultaneously while using a conventional microscope. An objective lens with a low numerical aperture (NA) has a large field of view but poor resolution. In contrast, a high NA objective lens will have a higher resolution but reduced field of view. In an effort to close the gap between these trade-offs, we introduce an acoustofluidic scanning nanoscope (AS-nanoscope) that can simultaneously achieve high resolution with a large field of view. The AS-nanoscope relies on acoustofluidic-assisted scanning of multiple microsized particles. A scanned 2D image is then compiled by processing the microparticle images using an automated big-data image algorithm. The AS-nanoscope has the potential to be integrated into a conventional microscope or could serve as a stand-alone instrument for a wide range of applications where both high resolution and large field of view are required.

Indexed as

acoustic streamingacoustofluidicsimage processingscanning nanoscopesuper resolution

Identifiers

PMID32574033
PMCPMC7438315

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.