Evidence map›Paper›PMID 32573944›Full record

ArticleJournal of cellular and molecular medicine2020

A combined CaMKII inhibition and mineralocorticoid receptor antagonism via eplerenone inhibits functional deterioration in chronic pressure overloaded mice.

Helen E Driessen, Magda S Fontes, Leonie van Stuijvenberg, Maike A Brans, Marie-Jose Goumans, Marc A Vos, Toon A van Veen

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Helen E DriessenDivision of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-6651-4528
Magda S FontesDivision of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Leonie van StuijvenbergDivision of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Maike A BransDivision of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Marie-Jose GoumansDepartment of Cell and Chemical Biology, LUMC, Leiden, The Netherlands.
Marc A VosDivision of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Toon A van VeenDivision of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
University Medical Center Utrecht · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the diseased and remodelled heart, increased activity and expression of Ca

Indexed as

AnimalsArrhythmias, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingDisease Models, AnimalEplerenoneFemaleFibrosisMaleMiceMice, Inbred C57BLMineralocorticoid Receptor AntagonistsReceptors, MineralocorticoidSignal TransductionSmad3 ProteinTransforming Growth Factor betaCalcium-Calmodulin-Dependent Protein Kinase Type 2EplerenoneMineralocorticoid Receptor AntagonistsReceptors, MineralocorticoidSmad3 ProteinTransforming Growth Factor betaCaMKIIcontractile performanceechocardiographyheart failuremineralocorticoid receptor antagonismpatchy fibrosisstrain analysis

Identifiers

PMID32573944
PMCPMC7412412
OpenAlexW3037265367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.