ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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36citing papers in PubMed, 3 pooled it
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Pooled it
- Linking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO.Functional & integrative genomics · 2025Pooled it
- A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.Molecular neurodegeneration · 2023Pooled it
- A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.Human genetics · 2026Article
- Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.Alzheimer's research & therapy · 2026Article
- Genetic analysis of neurodegenerative diseases.The Journal of clinical investigation · 2026Review
- Transcriptional signature of induced neurons differentiates virologically suppressed people with HIV from people without HIV.JCI insight · 2026Article
- Genetic association analyses of cognitive performance across multi-ancestry older adults: Application of Tobit models.Journal of Alzheimer's disease : JAD · 2025Article
- Plasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance.Brain, behavior, & immunity - health · 2025Article
- Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.medRxiv : the preprint server for health sciences · 2025Article
- Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.Alzheimer's research & therapy · 2025Article
- Epigenome-wide association study of cerebrospinal fluid-based biomarkers of Alzheimer's disease in cognitively normal individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- CD-Tron: Leveraging large clinical language model for early detection of cognitive decline from electronic health records.Journal of biomedical informatics · 2025Article
- CD-Tron: Leveraging Large Clinical Language Model for Early Detection of Cognitive Decline from Electronic Health Records.medRxiv : the preprint server for health sciences · 2025Article
- Gene and phenome-based analysis of the shared genetic architecture of eye diseases.American journal of human genetics · 2025Article
- Genetic implication of GABAFrontiers in pharmacology · 2025Review
- Genome-wide association neural networks identify genes linked to family history of Alzheimer's disease.Briefings in bioinformatics · 2024Article
- LIMO-GCN: a linear model-integrated graph convolutional network for predicting Alzheimer disease genes.Briefings in bioinformatics · 2024Article
- The Role of Neuropeptide Y in the Pathogenesis of Alzheimer's Disease: Diagnostic Significance and Neuroprotective Functions.Neurology international · 2024Review
- A Transcriptional Signature of Induced Neurons Differentiates Virologically Suppressed People Living With HIV from People Without HIV.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
21 authors at 14 institutions in 3 countries.
Richard ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
Alden GrossJohns Hopkins Bloomberg School of Public Health, Johns Hopkins Center on Aging and Health, Baltimore, Maryland, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Ryan KoestererPrograms in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Philippe AmouyelInserm, CHU Lille, Institute Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of age-related diseases; Institute Pasteur de Lille, University of Lille, Lille Cedex, France.
Celine BellenguezInserm, CHU Lille, Institute Pasteur de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of age-related diseases; Institute Pasteur de Lille, University of Lille, Lille Cedex, France.
Carole DufouilInserm Unit 1219 Bordeaux Population Health, CIC 1401-EC (Clinical Epidemiology), University of Bordeaux, ISPED (Bordeaux School of Public Health), Bordeaux University Hospital, Bordeaux, France.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Lori ChibnikDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Carlos CruchagaHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA.
Jorge Del-AguilaHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA.
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Leanne MunsieEli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
Ashley WinslowOrphan Disease Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, Pennsylvania, USA.
Stephen NewhouseDepartment of Biostatistics and Health Informatics, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Andrew J SaykinIndiana Alzheimer Disease Center and Department of Radiology and Imaging Sciences, IU Health Neuroscience Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
John S K KauweDepartment of Biology, Brigham Young University, Provo, Utah, USA.
Alzheimer's Disease Genetics ConsortiumDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Robert C GreenDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Broad Institute · USBoston University · USInserm · FRUniversity of Washington · USWashington University in St. Louis · USBrigham Young University · USEli Lilly (United States) · USIndiana University Health · USJohns Hopkins University · USNewYork–Presbyterian Hospital · USRush University Medical Center · USUniversité de Bordeaux · FRUniversity of London · GBUniversity of Pennsylvania · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MTranslational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MSatellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MThe National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family-Based Study (FBS)U24AG056270 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, TATIANA M. FOROUD · 2017 to 2026
$31.4MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV · 2020 to 2026
$29.0MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MNIA NIH HHS K25 AG055620NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066509NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS R01 AG015801NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG042437NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG057777NIA NIH HHS R01 AG058501NIA NIH HHS R01 AG064877NIA NIH HHS R01 AG067501NIA NIH HHS RF1 AG044546NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG058501NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG052411NIA NIH HHS U01 AG058922NIA NIH HHS U19 AG066567NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG056270NIH HHS P01AG003991NIH HHS P01 AG026276NIH HHS P30AG10161NIH HHS P50 AG05681NIH HHS R01AG042437NIH HHS R01AG044546NIH HHS R01AG05777NIH HHS R01AG058501NIH HHS R01AG15819NIH HHS R01AG17917NIH HHS RF1AG053303NIH HHS U01AG052411NIH HHS U01AG058922
Abstract
introductionVariability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with AD.
methodsWe tested for interactions between genetic variants and time since diagnosis to predict the ROD of a composite cognitive score in 3946 AD cases and performed pathway analysis on the top genes.
resultsSuggestive associations (P < 1.0 × 10 DISCUSSION: Pathways related to AD, intelligence, and neurological function determine AD progression, while previously identified AD risk variants, including the apolipoprotein (APOE) ε4 and ε2 variants, do not have a major impact.
Indexed as
AgedAged, 80 and overAlzheimer DiseaseCognitive DysfunctionDisease ProgressionFemaleGenetic VariationGenome-Wide Association StudyHumansMalecognitive declinedisease progressiongenetic associationpathway analysis
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