ArticleTransplant infectious disease : an official journal of the Transplantation Society2020
COVID-19 pneumonia in kidney transplant recipients: Focus on immunosuppression management.
Article in Transplant infectious disease : an official journal of the Transplantation Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- The Management of Immunosuppression in Kidney Transplant Recipients with COVID-19 Disease: An Update and Systematic Review of the Literature.Medicina (Kaunas, Lithuania) · 2021Pooled it
- COVID-19 in immunocompromised patients: A systematic review of cancer, hematopoietic cell and solid organ transplant patients.The Journal of infection · 2021Pooled it
- Management of Kidney Transplant Outpatients With COVID-19: A Single Center Experience.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Adequacy to immunosuppression management guidelines in kidney transplant recipients with severe COVID-19 pneumonia: a practice survey.Frontiers in transplantation · 2024Article
- A Scoping Review of the Impact of COVID-19 on Kidney Transplant Patients in the United States.Cureus · 2023Article
- Kidney Allograft Rejection and Coronavirus Disease 2019 Infection: A Narrative Review.Advanced biomedical research · 2023Review
- Multiple Post-SARS-COV2 Infectious Complications in Kidney Transplant Recipient.Medicina (Kaunas, Lithuania) · 2022Article
- Article
- COVID-19 and corticosteroids: a narrative review.Inflammopharmacology · 2022Review
- Survival and clinical outcomes of kidney transplant recipients with coronavirus disease infection: An updated systematic review and meta-analysis.Turkish journal of urology · 2022Article
- Covid-19 in kidney transplant recipients with immunosuppressive therapy.Caspian journal of internal medicine · 2022Review
- COVID-19 in renal transplant recipients and general population: a comparative study of clinical, laboratory, and radiological features, severity, and outcome.Virology journal · 2021Article
- Mortality risk factors in kidney-transplanted patients with COVID-19: A systematic review and regression analysis.Health science reports · 2021Article
- Impact of immunosuppression on the immune response to SARS-CoV-2 infection: A mechanistic study.Transplant infectious disease : an official journal of the Transplantation Society · 2021Article
- Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- SARS-CoV-2 in Solid Organ Transplant Recipients: A Structured Review of 2020.Transplantation proceedings · 2021Review
- The Impact of COVID-19 on Kidney Transplant Recipients in Pre-Vaccination and Delta Strain Era: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- COVID-19 reinfection or reactivation in a renal transplant patient.Clinical case reports · 2021Article
- The impact of COVID-19 on kidney transplantation and the kidney transplant recipient - One year into the pandemic.Transplant international : official journal of the European Society for Organ Transplantation · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe coronavirus disease of 2019, also known as COVID-19, has been declared a global pandemic. Significant controversies exist regarding treatment modalities for this novel disease, especially in immunocompromised patients. Experience with management of COVID-19 in kidney transplant recipients is scarce; effects of this virus on immunosuppressed individuals are not well understood.
methodsWe identified 30 renal transplant recipients with confirmed COVID-19 pneumonia who were admitted to inpatient between March 2020 and April 2020. All patients received a 5-day course of hydroxychloroquine and azithromycin; half of the patients received methylprednisolone. During hospitalization, calcineurin inhibitors and antimetabolites were held; prednisone was continued.
resultsClinical presentation of flu-like symptoms was similar to those in the general population. Hyponatremia, lymphopenia, acute kidney injury, and elevated inflammatory markers were common. Over the course of follow-up, 23 have been discharged home with a functioning allograft and in stable condition; 4 experienced acute kidney injury requiring renal replacement therapy; 7 patients were intubated, and 6 expired. The mortality rate in our cohort was 20%.
conclusionOur findings described the characteristics and outcomes of this highly fatal illness in a multi-ethnic kidney transplant cohort, with insights on immunosuppression management that could further our understanding of this unique disease in immunocompromised populations.
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