ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020
Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Structural and biochemical characterization of yeast Tcd enzymes installing the post-transcriptional modification ct6A in tRNA.Nucleic acids research · 2026Article
- The "Bagno dell'Acqua" Lake as a Novel Mars-like Analogue: Prebiotic Syntheses of PNA and RNA Building Blocks and Oligomers.International journal of molecular sciences · 2025Article
- Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem : a European journal of chemical biology · 2025Review
- Traces of a Primitive RNA Ring in Current Genomes.Biology · 2025Article
- Article
- The Origin of Translation: Bridging the Nucleotides and Peptides.International journal of molecular sciences · 2022Review
- Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural Insights.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks.The Journal of organic chemistry · 2022Article
- Article
- Review
- The RNA methyltransferase METTL8 installs mNature communications · 2022Article
- The "Water Problem"(Life (Basel, Switzerland) · 2021Review
- Efficient access to 3'-RSC advances · 2021Article
- Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
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Authors and funding
7 authors.
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Abstract
Fossils of extinct species allow us to reconstruct the process of Darwinian evolution that led to the species diversity we see on Earth today. The origin of the first functional molecules able to undergo molecular evolution and thus eventually able to create life, are largely unknown. The most prominent idea in the field posits that biology was preceded by an era of molecular evolution, in which RNA molecules encoded information and catalysed their own replication. This RNA world concept stands against other hypotheses, that argue for example that life may have begun with catalytic peptides and primitive metabolic cycles. The question whether RNA or peptides were first is addressed by the RNA-peptide world concept, which postulates a parallel existence of both molecular species. A plausible experimental model of how such an RNA-peptide world may have looked like, however, is absent. Here we report the synthesis and physicochemical evaluation of amino acid containing adenosine bases, which are closely related to molecules that are found today in the anticodon stem-loop of tRNAs from all three kingdoms of life. We show that these adenosines lose their base pairing properties, which allow them to equip RNA with amino acids independent of the sequence context. As such we may consider them to be living molecular fossils of an extinct molecular RNA-peptide world.
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