Evidence map›Paper›PMID 32573812›Full record

ArticleClinical transplantation2020

Financial impact of delayed graft function in kidney transplantation.

Daniel W Kim, Demetra Tsapepas, Kristen L King, S Ali Husain, Frank A Corvino, Allison Dillon, Weiying Wang, Tracy J Mayne, Sumit Mohan

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Clinical transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07726134 (A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients), which is not on this map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07726134 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2028Enrolled160ConditionsDelayed Graft Function, Kidney TransplantationArmsFurosemide, Mannitol
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 71 citations in OpenAlex.

  1. Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Daniel W KimDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0003-0968-4456
Demetra TsapepasColumbia University Renal Epidemiology (CURE) Group, New York, NY, USA.ORCID 0000-0001-6428-5525
Kristen L KingDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-7920-7615
S Ali HusainDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-1823-0117
Frank A CorvinoGenesis Research, Hoboken, NY, USA.
Allison DillonGenesis Research, Hoboken, NY, USA.
Weiying WangGenesis Research, Hoboken, NY, USA.
Tracy J MayneAngion BioMedica, Uniondale, New York, USA.
Sumit MohanDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-5305-9685
Columbia University Irving Medical Center · USGenesis Research Institute · JPAngion (United States) · USNewYork–Presbyterian Hospital · US

Funding

Institutional Career Development CoreKL2TR001874 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GENKINGER, JEANINE M., SHIMBO, DAICHI · 2016 to 2025
$13.6M
5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116066 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sumit Mohan, Deirdre Sawinski · 2017 to 2026
$2.5M
Identifying and exploring solutions to the ethical challenges of ApoL1 testing of donors with recent African ancestry through mixed methods research with stakeholdersR01MD014161 · NIMHD · WASHINGTON UNIVERSITY · PI DUBOIS, JAMES M, MOHAN, SUMIT · 2019 to 2021
$1.2M
Increasing Minority Population Awareness through Community Teaching for Improved Organ Donation (IMPACT for Improved Organ Donation)R01DK114893 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHAN, SUMIT · 2017 to 2021
$1.2M
NCATS NIH HHS KL2 TR001874NIDDK NIH HHS R01 DK114893NIDDK NIH HHS U01 DK116066NIMHD NIH HHS R01 MD014161
6 · The paper itself

Abstract

Increased utilization of suboptimal organs in response to organ shortage has resulted in increased incidence of delayed graft function (DGF) after transplantation. Although presumed increased costs associated with DGF are a deterrent to the utilization of these organs, the financial burden of DGF has not been established. We used the Premier Healthcare Database to conduct a retrospective analysis of healthcare resource utilization and costs in kidney transplant patients (n = 12 097) between 1/1/2014 and 12/31/2018. We compared cost and hospital resource utilization for transplants in high-volume (n = 8715) vs low-volume hospitals (n = 3382), DGF (n = 3087) vs non-DGF (n = 9010), and recipients receiving 1 dialysis (n = 1485) vs multiple dialysis (n = 1602). High-volume hospitals costs were lower than low-volume hospitals ($103 946 vs $123 571, P < .0001). DGF was associated with approximately $18 000 (10%) increase in mean costs ($130 492 vs $112 598, P < .0001), 6 additional days of hospitalization (14.7 vs 8.7, P < .0001), and 2 additional ICU days (4.3 vs 2.1, P < .0001). Multiple dialysis sessions were associated with an additional $10 000 compared to those with only 1. In conclusion, DGF is associated with increased costs and length of stay for index kidney transplant hospitalizations and payment schemes taking this into account may reduce clinicians' reluctance to utilize less-than-ideal kidneys.

Indexed as

Kidney TransplantationDelayed Graft FunctionGraft RejectionGraft SurvivalHumansKidneyRetrospective StudiesRisk Factorsdelayed graft functiondialysiskidney diseasekidney transplant

Identifiers

PMID32573812
PMCPMC8415124
OpenAlexW3037965808

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.