ArticleNucleic acids research2020
METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.
Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Pseudouridine synthase PUS1 and initiation factor mtIF2 are human mitoribosomal small subunit assembly factors.Nature communications · 2026Article
- Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome.Structure (London, England : 1993) · 2025Article
- METTL Family in Healthy and Disease.Molecular biomedicine · 2024Review
- Article
- Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.Cell discovery · 2024Article
- The catalytic activity of methyltransferase METTL15 is dispensable for its role in mitochondrial ribosome biogenesis.RNA biology · 2024Article
- The recognition mode between hsRBFA and mitoribosome 12S rRNA during mitoribosomal biogenesis.Nucleic acids research · 2023Article
- Integrated investigation of the clinical implications and targeted landscape for RNA methylation modifications in hepatocellular carcinoma.European journal of medical research · 2023Article
- Article
- TWIK-related acid-sensitive KiScience · 2022Article
- Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line.International journal of molecular sciences · 2022Article
- Organization and expression of the mammalian mitochondrial genome.Nature reviews. Genetics · 2022Review
- Article
- Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.International journal of molecular sciences · 2022Article
- [METTL27 is a prognostic biomarker of colon cancer and associated with immune invasion].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Williams-Beuren Syndrome Related Methyltransferase WBSCR27: From Structure to Possible Function.Frontiers in molecular biosciences · 2022Article
- RNA methylation in chloroplasts or mitochondria in plants.RNA biology · 2021Review
- Prespacers formed during primed adaptation associate with the Cas1-Cas2 adaptation complex and the Cas3 interference nuclease-helicase.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Quantitative density gradient analysis by mass spectrometry (qDGMS) and complexome profiling analysis (ComPrAn) R package for the study of macromolecular complexes.Biochimica et biophysica acta. Bioenergetics · 2021Article
- Novel dual methylation of cytidines in the RNA of mammals.Chemical science · 2021Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian mitochondrial ribosomes contain a set of modified nucleotides, which is distinct from that of the cytosolic ribosomes. Nucleotide m4C840 of the murine mitochondrial 12S rRNA is equivalent to the dimethylated m4Cm1402 residue of Escherichia coli 16S rRNA. Here we demonstrate that mouse METTL15 protein is responsible for the formation of m4C residue of the 12S rRNA. Inactivation of Mettl15 gene in murine cell line perturbs the composition of mitochondrial protein biosynthesis machinery. Identification of METTL15 interaction partners revealed that the likely substrate for this RNA methyltransferase is an assembly intermediate of the mitochondrial small ribosomal subunit containing an assembly factor RBFA.
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