Evidence map›Paper›PMID 32573705›Full record

ArticleBioinformatics (Oxford, England)2020

Programmatic access to bacterial regulatory networks with regutools.

Joselyn Chávez, Carmina Barberena-Jonas, Jesus E Sotelo-Fonseca, José Alquicira-Hernández, Heladia Salgado, Leonardo Collado-Torres, Alejandro Reyes

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joselyn ChávezDepartamento de Microbiología Molecular, Instituto de Biotecnología.
Carmina Barberena-JonasPrograma de Genómica Computacional, Centro de Ciencias Genómicas.
Jesus E Sotelo-FonsecaPrograma de Genómica Computacional, Centro de Ciencias Genómicas.
José Alquicira-HernándezPrograma de Genómica Computacional, Centro de Ciencias Genómicas.
Heladia SalgadoPrograma de Genómica Computacional, Centro de Ciencias Genómicas.
Leonardo Collado-TorresLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Alejandro ReyesDepartment of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Funding

HIGH THROUGHPUT LITERATURE CURATION OF GENETIC REGULATION IN BACTERIAL MODELSR01GM110597 · NIGMS · CENTER FOR GENOMIC SCIENCES · PI COLLADO-VIDES, JULIO · 2015 to 2018
$1.6M
NIGMS NIH HHS R01 GM110597
6 · The paper itself

Abstract

summaryRegulonDB has collected, harmonized and centralized data from hundreds of experiments for nearly two decades and is considered a point of reference for transcriptional regulation in Escherichia coli K12. Here, we present the regutools R package to facilitate programmatic access to RegulonDB data in computational biology. regutools gives researchers the possibility of writing reproducible workflows with automated queries to RegulonDB. The regutools package serves as a bridge between RegulonDB data and the Bioconductor ecosystem by reusing the data structures and statistical methods powered by other Bioconductor packages. We demonstrate the integration of regutools with Bioconductor by analyzing transcription factor DNA binding sites and transcriptional regulatory networks from RegulonDB. We anticipate that regutools will serve as a useful building block in our progress to further our understanding of gene regulatory networks. AVAILABILITY AND IMPLEMENTATION: regutools is an R package available through Bioconductor at bioconductor.org/packages/regutools.

Indexed as

EcosystemEscherichia coli K12Computational BiologyGene Regulatory NetworksSoftware

Identifiers

PMID32573705
PMCPMC7575047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.