Evidence map›Paper›PMID 32573339›Full record

ArticleEpigenetics2020

Age-related epigenetic drift deregulates

Magdalena Owczarz, Jacek Połosak, Anna Domaszewska-Szostek, Paulina Kołodziej, Alina Kuryłowicz, Monika Puzianowska-Kuźnicka

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Magdalena OwczarzDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS , Warsaw, Poland.
Jacek PołosakDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS , Warsaw, Poland.ORCID 0000-0002-0033-2043
Anna Domaszewska-SzostekDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS , Warsaw, Poland.
Paulina KołodziejDepartment of Geriatrics and Gerontology, Medical Centre of Postgraduate Education , Warsaw, Poland.ORCID 0000-0001-5710-3252
Alina KuryłowiczDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS , Warsaw, Poland.
Monika Puzianowska-KuźnickaDepartment of Human Epigenetics, Mossakowski Medical Research Centre PAS , Warsaw, Poland.
Mossakowski Medical Research Institute, Polish Academy of Sciences · PLPostgraduate School of Molecular Medicine · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in

Indexed as

Epigenesis, GeneticGene Expression Regulation, DevelopmentalAdultAgedCells, CulturedCpG IslandsDNA MethylationFemaleGene Regulatory NetworksHumansLeukocytes, MononuclearMaleMicroRNAsMiddle AgedProto-Oncogene Proteins c-mycSirtuinsMicroRNAsMYC protein, humanProto-Oncogene Proteins c-mycSIRT6 protein, humanSirtuinsTP53 protein, humanTumor Suppressor Protein p53aginginteraction networklongevitymethylationmiRNAperipheral blood mononuclear cells (PBMCs)SIRT6

Identifiers

PMID32573339
PMCPMC7678931
OpenAlexW3037422943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.