Evidence map›Paper›PMID 32573327›Full record

ArticleEpigenetics2020

Prenatal smoke exposure induces persistent

Khosbayar Lkhagvadorj, Karolin F Meyer, Laura P Verweij, Wierd Kooistra, Marjan Reinders-Luinge, Henk W Dijkhuizen, Inge A M de Graaf, Torsten Plösch, Machteld N Hylkema

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Khosbayar LkhagvadorjDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.ORCID 0000-0002-5718-4256
Karolin F MeyerDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.ORCID 0000-0003-2365-7964
Laura P VerweijDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
Wierd KooistraDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
Marjan Reinders-LuingeDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
Henk W DijkhuizenFaculty of Science and Engineering, University of Groningen , Groningen, The Netherlands.
Inge A M de GraafDepartment of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute of Pharmacy, University of Groningen , Groningen, The Netherlands.
Torsten PlöschDepartment of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.
Machteld N HylkemaDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen , Groningen, The Netherlands.ORCID 0000-0002-6732-8903
University Medical Center Groningen · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal smoke exposure (PSE) is a risk factor for nicotine dependence. One susceptibility gene for nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine and nicotine clearance in the liver. Higher activity of the CYP2A6 enzyme is associated with nicotine dependence, but no research has addressed the PSE effects on the

Indexed as

DNA MethylationAnimalsAryl Hydrocarbon HydroxylasesCpG IslandsCytochrome P450 Family 2FemaleLiverMaleMiceMice, Inbred C57BLNicotinePregnancyPrenatal Exposure Delayed EffectsPromoter Regions, GeneticRNA, MessengerTobacco Smoke PollutionAryl Hydrocarbon HydroxylasesCyp2a5 protein, mouseCytochrome P450 Family 2NicotineRNA, MessengerTobacco Smoke PollutioncotinineCYP2A5epigeneticsmouse modelnicotine dependencePrenatal smoke exposuresex difference

Identifiers

PMID32573327
PMCPMC7678918
OpenAlexW3037303443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.