Evidence map›Paper›PMID 32572999›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2020

Decidual memory T-cell subsets and memory T-cell stimulatory cytokines in early- and late-onset preeclampsia.

Tom E C Kieffer, Anne Laskewitz, Annegé Vledder, Sicco A Scherjon, Marijke M Faas, Jelmer R Prins

Open access · hybridAbstract read
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Systemic and Local Immunological Markers in Preeclampsia.Diagnostics (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Memory regulatory T cells in pregnancy.Frontiers in immunology · 2023
    Review
  11. Review
  12. Update on Immune Mechanisms in Hypertension.American journal of hypertension · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Decidual memory T-cell subsets and memory T-cell stimulatory cytokines in early- and late-onset preeclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tom E C KiefferDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-0375-5022
Anne LaskewitzDivision of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Annegé VledderDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sicco A ScherjonDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marijke M FaasDivision of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jelmer R PrinsDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-3984-2163
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

problemPreeclampsia is a major cause of fetal and maternal mortality and morbidity. Disturbed fetal-maternal immune tolerance, and therewith memory T cells, might be involved in its etiology. This study aims to give insight into memory T-cell populations and its associated cytokines in the decidual layers in early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE). METHOD OF STUDY: Lymphocytes were isolated from the decidua parietalis and basalis from EO-PE (n = 6), LO-PE (n = 8) and healthy (n = 15) pregnancies. CD4

resultsCD4

conclusionIn conclusion, decidual memory T-cell proportions, their activation status, and associated cytokines are altered in preeclampsia and might therefore be involved in fetal-maternal immune tolerance and the pathophysiology of preeclampsia.

Indexed as

AdultAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD69 AntigensCD8-Positive T-LymphocytesCytokinesDeciduaDisease ProgressionFemaleHumansImmune ToleranceImmunologic MemoryLectins, C-TypeLymphocyte ActivationPre-EclampsiaAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCytokinesLectins, C-Typedeciduaearly-onset preeclampsialate-onset preeclampsiamemory T cellpregnancy

Identifiers

PMID32572999
PMCPMC7540032
OpenAlexW3037941654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.