ArticleJournal of neurovirology2020
Neurocognitive impairment and gray matter volume reduction in HIV-infected patients.
Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Implications of HIV persistence and pathogenesis in microglia.Current opinion in HIV and AIDS · 2026Review
- Cortical folding pattern of asymptomatic HIV-associated neurocognitive disorders.BMC medical imaging · 2025Article
- Incarcerated adolescents scoring high on the Brown Attention-Deficit Disorder Scale are characterized by impairments within brain regions associated with executive control: A source-based morphometry study.Psychiatry research. Neuroimaging · 2025Article
- HIV, smoking, and the brain: a convergence of neurotoxicities.AIDS research and therapy · 2025Review
- Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.Frontiers in neurology · 2025Review
- Attention-Enhanced Fusion of Structural and Functional MRI for Analyzing HIV-Associated Asymptomatic Neurocognitive Impairment.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024Article
- White and Gray Matter Changes are Associated With Neurocognitive Decline in HIV Infection.Annals of neurology · 2024Article
- An Integrative Approach to the Current Treatment of HIV-Associated Neurocognitive Disorders and the Implementation of Leukemia Inhibitor Factor as a Mediator of Neurocognitive Preservation.Life (Basel, Switzerland) · 2023Review
- Cerebral abnormalities in HIV-infected individuals with neurocognitive impairment revealed by fMRI.Scientific reports · 2023Article
- Role of microglia in HIV-1 infection.AIDS research and therapy · 2023Review
- Additive cortical gray matter deficits in people living with HIV who use cocaine.Journal of neurovirology · 2023Article
- Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.Journal of neurovirology · 2023Article
- Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks.Scientific reports · 2022Article
- Morphological Changes of Frontal Areas in Male Individuals With HIV: A Deformation-Based Morphometry Analysis.Frontiers in neurology · 2022Article
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Review
- Mechanisms of neuronal dysfunction in HIV-associated neurocognitive disorders.Cellular and molecular life sciences : CMLS · 2021Review
- Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit.PloS one · 2021Article
- Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool.Frontiers in neuroscience · 2021Article
- Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV.NeuroImage. Clinical · 2021Article
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Authors and funding
9 authors.
Funding
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Abstract
Although neuropsychological studies of human immunodeficiency virus (HIV)-infected patients have demonstrated heterogeneity in neurocognitive impairment and neuroimaging studies have reported diverse brain regions affected by HIV, it remains unclear whether individual differences in neurocognitive impairment are underpinned by their neural bases. Here, we investigated spatial distribution patterns of correlation between neurocognitive function and regional gray matter (GM) volume across patients with HIV. Thirty-one combination antiretroviral therapy-treated HIV-infected Japanese male patients and 33 age- and sex-matched healthy controls were included in the analysis after strict exclusion criteria, especially for substance use. Fifteen neurocognitive tests were used, and volumetric magnetic resonance imaging was performed. We used voxel-based morphometry to compare GM volume between groups and identify regional GM volumes that correlated with neurocognitive tests across patients. Using the Frascati criteria, 10 patients were diagnosed with asymptomatic neurocognitive impairment, while the others were not diagnosed with HIV-associated neurocognitive disorders. Patients showed a significantly lower performance in five neurocognitive tests as well as significantly reduced GM volume relative to controls, with volume-reduced regions spread diffusely across the whole brain. Different aspects of neurocognitive impairment (i.e., figural copy, finger tapping, and Pegboard) were associated with different GM regions. Our findings suggest a biological background constituting heterogeneity of neurocognitive impairment in HIV infection and support the clinical importance of considering individual differences for tailor-made medicine for people living with HIV.
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