Evidence map›Paper›PMID 32572830›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020

The Use of the Selective Imidazoline I

Laura Micheli, Lorenzo Di Cesare Mannelli, Fabio Del Bello, Mario Giannella, Alessandro Piergentili, Wilma Quaglia, Donatello Carrino, Alessandra Pacini, Carla Ghelardini

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. The dual role of VEGF-A in a complex in vitro model of oxaliplatin-induced neurotoxicity: Pain-related and neuroprotective effects.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Efficacy of a vegetal mixture composed ofFrontiers in nutrition · 2022
    Article
  12. Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Article
  13. Review
  14. Efficacy ofMarine drugs · 2021
    Article
  15. Aligning New Approaches to Accelerate the Development of Non-opioid Analgesic Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura MicheliDept. of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139, Florence, Italy.
Lorenzo Di Cesare MannelliDept. of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139, Florence, Italy. lorenzo.mannelli@unifi.it.ORCID http://orcid.org/0000-0001-8374-4432
Fabio Del BelloSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
Mario GiannellaSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
Alessandro PiergentiliSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
Wilma QuagliaSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, 62032, Camerino, Italy.
Donatello CarrinoDepartment of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Alessandra PaciniDepartment of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Carla GhelardiniDept. of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139, Florence, Italy.
University of Florence · ITUniversità di Camerino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-cancer therapy based on the repeated administration of oxaliplatin is limited by the development of a disabling neuropathic syndrome with detrimental effects on the patient's quality of life. The lack of effective pharmacological approaches calls for the identification of innovative therapeutic strategies based on new targets. We focused our attention on the imidazoline I

Indexed as

AnimalsAntineoplastic AgentsDose-Response Relationship, DrugDrug Evaluation, PreclinicalHT29 CellsHumansImidazolesImidazoline ReceptorsMiceNeuralgiaOxaliplatinPain MeasurementAntineoplastic AgentsimidazoleImidazolesimidazoline I1 receptorsImidazoline ReceptorsOxaliplatinastrocytescarbophenylinechemotherapy-induced neuropathic painImidazoline I1 receptor agonistoxaliplatin

Identifiers

PMID32572830
PMCPMC7609613
OpenAlexW3036338297

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.