Evidence map›Paper›PMID 32572724›Full record

ArticleInflammopharmacology2020

Antinociceptive effect of Lonchocarpus araripensis lectin: activation of L-arginine/NO/cGMP/K

Ana Maria S Assreuy, Renata Morais Ferreira Amorim, Stephanie Lian Martins, Maria Gleiciane de Queiroz Martins, João Batista Cajazeiras, Mayara Torquato Lima da Silva, Alana Freitas Pires, Kyria Santiago Nascimento, Benildo Sousa Cavada, Mário Rogério Lima Mota

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Targeting L-arginine/NO/cGMP/KFrontiers in pharmacology · 2025
    Review
  2. Article
  3. Review
  4. Functional Regulation of KFrontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ana Maria S AssreuyInstituto Superior de Ciências Biomédicas, Universidade Estadual Do Ceará, Av. Dr. Silas Munguba, 1700, Fortaleza, CE, 60740-000, Brazil. anassreuy@gmail.com.ORCID http://orcid.org/0000-0002-2323-5385
Renata Morais Ferreira AmorimInstituto Superior de Ciências Biomédicas, Universidade Estadual Do Ceará, Av. Dr. Silas Munguba, 1700, Fortaleza, CE, 60740-000, Brazil.
Stephanie Lian MartinsInstituto Superior de Ciências Biomédicas, Universidade Estadual Do Ceará, Av. Dr. Silas Munguba, 1700, Fortaleza, CE, 60740-000, Brazil.
Maria Gleiciane de Queiroz MartinsPrograma de Pós-Graduação Em Biotecnologia, Centro Universitário INTA (UNINTA), Rua Cel Antônio Rodrigues Magalhães, 359, Sobral, CE, 62050-100, Brazil.
João Batista CajazeirasPrograma de Pós-Graduação Em Biotecnologia, Centro Universitário INTA (UNINTA), Rua Cel Antônio Rodrigues Magalhães, 359, Sobral, CE, 62050-100, Brazil.
Mayara Torquato Lima da SilvaDepartamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, SC, 88040-900, Brazil.
Alana Freitas PiresCentro de Ciências da Saúde, Unidade Via Corpvs, Centro Universitário Estácio Do Ceará, Rua Eliseu Uchoa Becco, 600, Fortaleza, CE, 60810-270, Brazil.
Kyria Santiago NascimentoLaboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Departamento de Bioquímica e Biologia Molecular, Universidade Federal Do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, 60440-970, Brazil.
Benildo Sousa CavadaLaboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Departamento de Bioquímica e Biologia Molecular, Universidade Federal Do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, 60440-970, Brazil.
Mário Rogério Lima MotaDepartamento de Farmácia, Odontologia e Enfermagem, Universidade Federal Do Ceará, Rua Alexandre Baraúna 949, Fortaleza, CE, 60430-170, Brazil.
Universidade Estadual do Ceará · BRUniversidade Federal do Ceará · BRInstituto Superior de Teologia Aplicada · BRCentro de Estudos em Psicologia da Saúde · BRUniversidade Federal de Santa Catarina · BR

Funding

CNPq 308433/2017-3
6 · The paper itself

Abstract

OBJECTIVE AND

designThe involvement of nitric oxide pathway in the antinociceptive activity of Lonchocarpus araripensis lectin (LAL) was investigated in the model of carragenan-induced hypernociception.

methodsSwiss mice received LAL (0.01-10 mg/kg; i.v.) 30 min before s.c. injection of carragenan in the paws. For the involvement of nociceptive pathways, animals were previously treated with the blockers: NOS (L-NAME, aminoguanidine, 7-nitroindazole); soluble guanylyl cyclase (ODQ); channels of ATP-dependent K

resultsLAL at all doses inhibited carrageenan-induced hypernociception (4.12 ± 0.58 g), being maximal at 10 mg/kg (3 h: 59%), and reversed by GlcNAc. At this time, LAL effect was reversed by nifedipine (39%), niflumic acid (59%), L-NAME (59%), 7-nitroindazole (44%), ODQ (45%), and glibenclamide (34%), but was unaltered by aminoguanidine. LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia.

conclusionThe antinociceptive effect of Lonchocarpus araripensis lectin involves activation of the L-arginine/NO/GMPc/K

Indexed as

Adenosine TriphosphateAnalgesicsAnimalsArginineCarrageenanCyclic GMPFabaceaeGanglia, SpinalGene ExpressionKATP ChannelsLectinsMaleMiceNitric OxideNitric Oxide Synthase Type ISignal TransductionAdenosine TriphosphateAnalgesicsArginineCarrageenanCyclic GMPKATP ChannelsLectinsNitric OxideNitric Oxide Synthase Type IDalbergieae lectinHypernociceptionNitric oxidenNOS

Identifiers

PMID32572724
OpenAlexW3036627422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.