Evidence map›Paper›PMID 32572668›Full record

ArticleJournal of computer-aided molecular design2020

Distinct binding of cetirizine enantiomers to human serum albumin and the human histamine receptor H

Almudena Perona, M Piedad Ros, Alberto Mills, Antonio Morreale, Federico Gago

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Establishment of HAnalytical and bioanalytical chemistry · 2026
    Article
  2. A New GlyT2 Variant Associated with Hyperekplexia.International journal of molecular sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Almudena PeronaUniversidad Europea de Madrid, Urbanización El Bosque, c/ Tajo s/n, 28670, Villaviciosa de Odón, Madrid, Spain.ORCID 0000-0002-2402-4926
M Piedad RosUniversidad Europea de Madrid, Urbanización El Bosque, c/ Tajo s/n, 28670, Villaviciosa de Odón, Madrid, Spain.
Alberto MillsArea of Pharmacology, Department of Biomedical Sciences and "Unidad Asociada IQM-CSIC", School of Medicine and Health Sciences, University of Alcalá, 28805, Alcalá de Henares, Madrid, Spain.ORCID 0000-0003-4819-1638
Antonio MorrealeRepsol Technology Lab, c/ Agustín de Betancourt s/n, 28935, Móstoles, Madrid, Spain.ORCID 0000-0003-4236-0883
Federico GagoArea of Pharmacology, Department of Biomedical Sciences and "Unidad Asociada IQM-CSIC", School of Medicine and Health Sciences, University of Alcalá, 28805, Alcalá de Henares, Madrid, Spain. federico.gago@uah.es.ORCID 0000-0002-3071-4878
Universidad de Alcalá · ESRepsol (Spain) · ESUniversidad Complutense de Madrid · ESUniversidad Europea de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cetirizine, a major metabolite of hydroxyzine, became a marketed second-generation H

Indexed as

AnimalsBinding SitesCetirizineHistamine H1 Antagonists, Non-SedatingHorsesHumansProtein BindingReceptors, HistamineSerum AlbuminSerum Albumin, HumanStereoisomerismCetirizineHistamine H1 Antagonists, Non-SedatingReceptors, HistamineSerum AlbuminSerum Albumin, HumanAntihistaminesBinding affinityG-protein coupled receptorsHuman serum albuminMolecular dynamics simulations

Identifiers

PMID32572668
OpenAlexW3037876203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.