Evidence map›Paper›PMID 32572601›Full record

SynthesisInternational journal of colorectal disease2020

The value of circulation tumor DNA in predicting postoperative recurrence of colorectal cancer: a meta-analysis.

Rui Wang, Aiguang Zhao, Nida Cao, Zhaoyan Li, Guangtao Zhang, Feng Liu

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rui WangLongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Aiguang ZhaoLongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. aiguangzhao@qq.com.
Nida CaoLongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Zhaoyan LiLongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Guangtao ZhangLongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Feng LiuLongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSurgical resection is the primary treatment for patients with nonmetastatic colorectal cancer (CRC). However, even after undergoing radical resection procedure, 30-50% of patients will still experience relapse. Circulation tumor DNA (ctDNA), deriving from tumor cells, is shed into the bloodstream and is a potential predictive biomarker of recurrence in CRC. This meta-analysis was performed to identify the clinical value of ctDNA in predicting the recurrence of CRC patients in post-operative.

methodsPubMed, Embase, The Cochrane Library, and Web of Science were comprehensively searched to identify the studies that reported the function of ctDNA for predicting recurrence in CRC patients. The eligible studies were pooled to calculate the relative risk (RR) of recurrence in ctDNA positive and negative groups. The data of ctDNA on recurrence-free survival (RFS) were extracted and computed in hazard ratio (HR) and 95% confident interval (CI). Subgroup analyses were also performed.

resultsA total of 7 studies including 424 patients were included and analyzed in our meta-analysis. The results showed that pooled RR was 4.65 (95%CI: 2.68-8.08, P < 0.05), indicating ctDNA positive could predict the recurrence of CRC after curative surgical. The pooled HR demonstrated strong connection between ctDNA positive and RFS in patients with CRC (HR = 9.14, 95%CI: 4.02-20.75, P < 0.05).

conclusionEvidence from the meta-analysis suggested that ctDNA is a promising potential biomarker for predicting postoperative recurrence of CRC. Given the inherent limitations of this study, we look forward to more well-designed clinical studies to validate and update this analysis in the future.

Indexed as

Circulating Tumor DNAColorectal NeoplasmsHumansNeoplasm Recurrence, LocalPostoperative PeriodCirculating Tumor DNACirculation tumor DNAColorectal cancerMeta-analysisPredictionRecurrence

Identifiers

PMID32572601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.