Evidence map›Paper›PMID 32572588›Full record

ArticlePsychopharmacology2020

Amphetamine-induced striatal dopamine release in schizotypal personality disorder.

Judy L Thompson, Daniel R Rosell, Mark Slifstein, Xiaoyan Xu, Ethan G Rothstein, Yosefa A Modiano, Lawrence S Kegeles, Harold W Koenigsberg, Antonia S New, Erin A Hazlett and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Judy L ThompsonDepartment of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY, 14642, USA. judy_thompson@urmc.rochester.edu.ORCID http://orcid.org/0000-0001-8964-4934
Daniel R RosellDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mark SlifsteinDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, 11794, USA.
Xiaoyan XuDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.
Ethan G RothsteinDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Yosefa A ModianoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Lawrence S KegelesDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.
Harold W KoenigsbergDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Antonia S NewDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Erin A HazlettDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Margaret M McClureDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
M Mercedes Perez-RodriguezDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Larry J SieverDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Anissa Abi-DarghamDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, 11794, USA.
Icahn School of Medicine at Mount Sinai · USJames J. Peters VA Medical Center · USColumbia University · USStony Brook University · USFairfield University · USMichael E. DeBakey VA Medical Center · USRutgers, The State University of New Jersey · USThe Graduate Center, CUNY · US

Funding

Pharmacology of Cognition in Schizotypal Personality DisorderR01MH056140 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 1997 to 2011
$4.0M
Neurobiology of Affective Instability in Veterans at Low and High Risk for SuicideI01CX001451 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAZLETT, ERIN A. · 2017 to 2021
–
CTBI: Traumatic brain injury-induced inflammation effects on cognitive evaluations and response inhibition: Mechanisms of increased risk forsuicidalityI01CX002093 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GOODMAN, MARIANNE, HAZLETT, ERIN A. · 2020 to 2024
–
CSR&D Research Career Scientist Award ApplicationIK6CX001738 · VA · JAMES J PETERS VA MEDICAL CENTER · PI HAZLETT, ERIN A. · 2018 to 2022
–
CSRD VA I01 CX001451CSRD VA I01 CX002093CSRD VA IK6 CX001738NIMH NIH HHS MH56140U.S. Department of Veterans Affairs I01CX000609
6 · The paper itself

Abstract

rationalePrevious research has suggested that schizotypal personality disorder (SPD), a condition that shares clinical and cognitive features with schizophrenia, may be associated with elevated striatal dopamine functioning; however, there are no published studies of dopamine release within subregions of the striatum in SPD.

objectivesTo characterize dopamine release capacity in striatal subregions and its relation to clinical and cognitive features in SPD.

methodsWe used positron emission tomography with [

resultsThere were no significant group differences in BP

conclusionsIn contrast to previous findings, SPD was not associated with elevated striatal dopamine release. However, in SPD, there was a moderate positive association between ventral striatal dopamine release and severity of cognitive-perceptual symptoms, and negative associations between striatal dopamine release and severity of disorganized symptoms. Future larger scale investigations that allow for the separate examination of subgroups of participants based on clinical presentation will be valuable in further elucidating striatal DA functioning in SPD.

Indexed as

AdolescentAdultAmphetamineCorpus StriatumDopamineDopamine Uptake InhibitorsFemaleHumansMaleMemory, Short-TermMiddle AgedPositron-Emission TomographyRacloprideReceptors, Dopamine D2Schizotypal Personality DisorderYoung AdultAmphetamineDopamineDopamine Uptake InhibitorsDRD2 protein, humanRacloprideReceptors, Dopamine D2Disorganized symptomsDopaminePETPositive symptomsSchizophreniaSchizotypal personality disorderStriatumWorking memory

Identifiers

PMID32572588
OpenAlexW3036607942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.