Evidence map›Paper›PMID 32572566›Full record

ArticleEuropean radiology2020

Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative.

Magdalena Posadzy, Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, John A Lynch, Nancy E Lane, Thomas M Link

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Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. The ageing meniscus: Pathophysiology, epidemiology and management.Journal of experimental orthopaedics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Magdalena PosadzyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Lobby 6, Suite 350, San Francisco, CA, 94107, USA. magdalenaposadzy@gmail.com.ORCID http://orcid.org/0000-0002-6194-377X
Gabby B JosephDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Lobby 6, Suite 350, San Francisco, CA, 94107, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
John A LynchDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Nancy E LaneDepartment of Rheumatology, University of California, Davis, CA, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Lobby 6, Suite 350, San Francisco, CA, 94107, USA.
University of California, San Francisco · USUniversity of California, Davis · US

Funding

Understanding the mechanisms by which weight change affects progression of knee osteoarthritis in obese and overweight individuals: An analysis of the Osteoarthritis Initiative DatasetR01AR078917 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GABRIELLE JOSEPH, THOMAS M LINK · 2021 to 2026
$3.4M
Impact of Weight loss on Knee Joint Biochemical and Structural DegenerationR01AR064771 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINK, THOMAS M · 2014 to 2019
$1.6M
NIAMS NIH HHS R01 AR064771NIAMS NIH HHS R01 AR078917NIH HHS R01-AR064771
6 · The paper itself

Abstract

objectivesTo study the natural history of new horizontal meniscal tears and their association with progression of cartilage degeneration in individuals at risk for or with mild to moderate knee osteoarthritis over 4 years.

methodsIndividuals who developed a new meniscal tear in the right knee over 2 years were selected from the Osteoarthritis Initiative 3T MRI studies. Knee structural changes were analyzed at the time of tear appearance (baseline), and after 4 years using a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). Meniscal tears were classified as either horizontal tears or non-horizontal tears. Individuals without a meniscal tear were 1:3 frequency matched according to BMI, gender, race, and age and served as the control group. Linear regression analysis was used to compare cross-sectional and longitudinal changes in cartilage WORMS scores.

resultsForty-one subjects developed horizontal tears, including one indiviudal who developed a tear in both menisci, and 34 developed non-horizonal tears. We found that (29/41 (70.7%)) of horizontal and (20/34 (58.8%)) of non-horizonatal tears were stable during follow-up (p = 0.281). Although knees with an incident tear had higher than controls WORMS MAX total knee scores at baseline (coef. = 0.47, p = 0.044, 95% CI = 0.01 to 0.93), there were no significant differences between the horizontal subgroup and knees without tears in overall cartilage scores at baseline and in progression over 4 years of follow-up.

conclusionsNew horizontal meniscal tears tended to be stable over 4 years and presented no significant differences in progression of cartilage degeneration when compared with knees without tears. KEY POINTS: • Most of horizonal meniscal tears were stable over 4 years. • There were no statistically significant differences in overall progression of cartilage degenerative changes between knees with horizonal meniscal tears and control knees without tears • Horizontal tears most often occurred at the posterior horn of the medial meniscus and at the body of the lateral meniscus.

Indexed as

AgedCross-Sectional StudiesDisease ProgressionFemaleHumansKnee InjuriesKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneeRuptureSeverity of Illness IndexTibial Meniscus InjuriesMeniscusOsteoarthritisRisk factor

Identifiers

PMID32572566
OpenAlexW3036053879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.