Evidence map›Paper›PMID 32572565›Full record

ArticleArchives of dermatological research2021

Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo.

H Post, J E Hundt, G Zhang, R Depping, C Rose, E A Langan, R Paus

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of dermatological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

H Post *Department of Dermatology, University of Münster, Münster, Germany.
J E Hundt *Lübeck Institute for Experimental Dermatology, Lübeck, Germany.
G ZhangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai, China.
R DeppingInstitute of Physiology, University of Lübeck, Lübeck, Germany.
C RoseDepartment of Dermatology, University of Lübeck, Lübeck, Germany.
E A Langan *Department of Dermatology, University of Lübeck, Lübeck, Germany.
R Paus *Centre for Dermatology Research, University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester, UK. rxp803@med.miami.edu.
University of Lübeck · DEShanghai Ninth People's Hospital · CNUniversity of Manchester · GBUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired cutaneous wound healing remains a major healthcare challenge. The enormity of this challenge is compounded by the lack of preclinical human skin wound healing models that recapitulate selected key factors underlying impaired healing, namely hypoxia/poor tissue perfusion, oxidative damage, defective innervation, and hyperglycaemia. Since organ-cultured human skin already represents a denervated and impaired perfusion state, we sought to further mimic "pathological" wound healing conditions by culturing experimentally wounded, healthy full-thickness frontotemporal skin from three healthy female subjects for three days in either serum-free supplemented Williams' E medium or in unsupplemented medium under "pathological" conditions (i.e. hypoxia [5% O

Indexed as

AgedCell ProliferationCulture MediaDrug Evaluation, PreclinicalFemaleForeheadHumansHydrogen PeroxideKeratinocytesMiddle AgedNeovascularization, PhysiologicOxidative StressProof of Concept StudyRe-EpithelializationSkinThyroxineCulture MediaHydrogen PeroxideThyroxineEx vivoHypoxiaSkin modelWound healing

Identifiers

PMID32572565
PMCPMC7935818
OpenAlexW3035986123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.