Evidence map›Paper›PMID 32572562›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Tau PET imaging with

Elizabeth C Mormino, Tyler N Toueg, Carmen Azevedo, Jessica B Castillo, Wanjia Guo, Ayesha Nadiadwala, Nicole K Corso, Jacob N Hall, Audrey Fan, Alexandra N Trelle and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Evaluation of tau deposition usingAlzheimer's research & therapy · 2022
    Trial
  3. Evaluation of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  4. Associations of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. The relationships between ethnoracial identity, Aβ positivity, APOEε4, and medial temporal lobe tau PET.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  13. Exploring the origins of frequent tau-PET signal in vermal and adjacent regions.European journal of nuclear medicine and molecular imaging · 2025
    Article
  14. Kinetic modeling ofEJNMMI research · 2025
    Article
  15. TAU PET HARMONIZATION VIA SURFACE-BASED DIFFUSION MODEL.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025
    Article
  16. Establishing tau-PET cut-points for cognitive diagnosis withImaging neuroscience (Cambridge, Mass.) · 2025
    Article
  17. New Research on Biomarkers in Alzheimer's Continuum.Reviews on recent clinical trials · 2025
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Elizabeth C MorminoDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA. bmormino@stanford.edu.
Tyler N TouegDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Carmen AzevedoDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Jessica B CastilloDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Wanjia GuoDepartment of Psychology, Stanford University, Stanford, CA, USA.
Ayesha NadiadwalaDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Nicole K CorsoDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Jacob N HallDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Audrey FanDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Alexandra N TrelleDepartment of Psychology, Stanford University, Stanford, CA, USA.
Marc B HarrisonDepartment of Psychology, Stanford University, Stanford, CA, USA.
Madison P HuntDepartment of Psychology, Stanford University, Stanford, CA, USA.
Sharon J ShaDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Gayle DeutschDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Michelle JamesDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Carolyn A FredericksDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Mary Ellen KoranDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Michael ZeinehDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Kathleen PostonDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Michael D GreiciusDepartment of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Mehdi KhalighiDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Guido A DavidzonDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Bin ShenDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Greg ZaharchukDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.
Anthony D WagnerDepartment of Psychology, Stanford University, Stanford, CA, USA.
Frederick T ChinDepartment of Radiology, Stanford Medical School, Stanford, CA, USA.

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Victor Henderson · 2020 to 2026
$29.0M
Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI HENDERSON, VICTOR · 2015 to 2019
$7.9M
The impact of early Tau pathology on cognitive progression and neuropsychiatric symptoms in Parkinson's diseaseR01NS115114 · NINDS · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I., POSTON, KATHLEEN LOMBARD · 2019 to 2023
$4.2M
Iron as an Imaging Biomarker for Inflammation in ADR01AG061120 · NIA · STANFORD UNIVERSITY · PI ZEINEH, MICHAEL M · 2019 to 2023
$3.5M
High-resolution imaging of hippocampal mechanisms in age-related memory decline.R01AG048076 · NIA · STANFORD UNIVERSITY · PI WAGNER, ANTHONY D · 2014 to 2018
$1.9M
Influence of genetic risk factors on biomarkers and cognitive decline in preclinical ADK01AG051718 · NIA · STANFORD UNIVERSITY · PI MORMINO, ELIZABETH · 2016 to 2020
$642k
The impact of early medial temporal lobe Tau in human cognitive agingR21AG058859 · NIA · STANFORD UNIVERSITY · PI MORMINO, ELIZABETH · 2018 to 2019
$432k
NIA NIH HHS K01 AG051718NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG048076NIA NIH HHS R01 AG061120NIA NIH HHS R21 AG058859NINDS NIH HHS R01 NS115114
6 · The paper itself

Abstract

purposeIn vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer's disease (AD).

methodsForty-nine participants were scanned with

resultsSUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in

conclusionPreliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesAgedAged, 80 and overAgingAmyloid beta-PeptidesBrainCarbolinesHumansMiddle AgedPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesCarbolinestau ProteinsAlzheimer’s diseaseHuman agingNeurofibrillary tanglesTau PET

Identifiers

PMID32572562
PMCPMC7755737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.