Evidence map›Paper›PMID 32572242›Full record

ArticleNature immunology2020

Peripherally induced brain tissue-resident memory CD8

Stina L Urban, Isaac J Jensen, Qiang Shan, Lecia L Pewe, Hai-Hui Xue, Vladimir P Badovinac, John T Harty

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
  6. Immune signaling and function in neurodegeneration.The Journal of clinical investigation · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. CD103Nature communications · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stina L UrbanDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Isaac J JensenDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-3107-3961
Qiang ShanCenter for Discovery and Innovation, Hackensack University Medical Center, Hackensack, NJ, USA.
Lecia L PeweDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Hackensack, NJ, USA.ORCID http://orcid.org/0000-0002-9163-7669
Vladimir P BadovinacDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
John T HartyDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. john-harty@uiowa.edu.ORCID http://orcid.org/0000-0001-7266-2802
University of Iowa · USHackensack University Medical Center · US

Funding

TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
RESEARCH TRAINING IN INFECTIOUS DISEASEST32AI007343 · NIAID · UNIVERSITY OF IOWA · PI STAPLETON, JACK T. · 1988 to 2024
$5.0M
Regulation of primary and secondary CD4 and CD8 T cell memoryR37AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 2008 to 2017
$4.7M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Memory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4M
T resident memory in the lungR01AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T · 1998 to 2023
$4.4M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Cellular and molecular mechanisms controlling sepsis-induced immunoparalyses stateR35GM134880 · NIGMS · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P · 2020 to 2024
$1.9M
CD8+ T Cell effector mechanisms against L. monocytogenesR21AI042767 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T. · 2002 to 2002
$331k
Targeting Tcf/Lef-transcriptional program in leukemic stem cellsI01BX002903 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2016 to 2019
–
BLRD VA I01 BX000207BLRD VA I01 BX002903NIAID NIH HHS R01 AI042767NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874NIAID NIH HHS R21 AI042767NIAID NIH HHS R37 AI042767NIAID NIH HHS T32 AI007343NIAID NIH HHS T32 AI007511NIGMS NIH HHS R35 GM134880
6 · The paper itself

Abstract

The central nervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interactions between the peripheral immune system and CNS in controlling infections and tissue homeostasis. Tissue-resident memory (T

Indexed as

AnimalsBacterial InfectionsBrainCD8-Positive T-LymphocytesCentral Nervous System InfectionsImmunologic MemoryLymphocyte ActivationMiceVirus Diseases

Identifiers

PMID32572242
PMCPMC7381383
OpenAlexW3036169904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.