ArticleNature neuroscience2020
Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- A lifespan staging model of basal forebrain cholinergic vulnerability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation.Nature communications · 2026Article
- Microglia Modulate Information Processing in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Selective attention to auditory and visual modalities converges onto noncholinergic basal forebrain neurons.Science advances · 2026Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways.Brain : a journal of neurology · 2025Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.bioRxiv : the preprint server for biology · 2025Article
- Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes.Science advances · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty.eLife · 2025Article
- GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli.Communications biology · 2025Article
- Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission.Frontiers in neural circuits · 2025Review
- Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models.Translational neurodegeneration · 2024Article
- Distinct septo-hippocampal cholinergic projections separately mediate stress-induced emotional and cognitive deficits.Science advances · 2024Article
- Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning.Nature neuroscience · 2024Article
- Multimodal gradients of basal forebrain connectivity across the neocortex.Nature communications · 2024Article
- NgfrNature communications · 2024Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. However, whether distinct types of BFCNs support different functions remains unclear. Therefore, we recorded BFCNs in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties. We identified two distinct types of BFCNs that differ in their firing modes, synchronization properties and behavioral correlates. Bursting cholinergic neurons (Burst-BFCNs) fired synchronously, phase-locked to cortical theta activity and fired precisely timed bursts after reward and punishment. Regular-firing cholinergic neurons (Reg-BFCNs) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and responded with precise single spikes after behavioral outcomes. In an auditory detection task, synchronization of Burst-BFCNs to the auditory cortex predicted the timing of behavioral responses, whereas tone-evoked cortical coupling of Reg-BFCNs predicted correct detections. We propose that differential recruitment of two basal forebrain cholinergic neuron types generates behavior-specific cortical activation.
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