ArticleNature biomedical engineering2020
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals.Science advances · 2026Article
- From lipofuscin accumulation to cellular dysfunction: a focus on liver pathophysiology.Histochemistry and cell biology · 2026Review
- Label-free tissue NIR-II autofluorescence imaging for visualization of human liver malignancy.Nature biomedical engineering · 2026Article
- Nano-Reagents in Acute Pancreatitis: Diagnostic, Therapeutic, and Theranostic Advances.International journal of nanomedicine · 2026Review
- Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.Diabetes, obesity & metabolism · 2025Article
- Valence and Site Engineering Enable Efficient Broadband Near-Infrared Emission at 960 nm in CrAdvanced materials (Deerfield Beach, Fla.) · 2025Article
- Article
- Senescent-like border-associated macrophages regulate cognitive aging via migrasome-mediated induction of paracrine senescence in microglia.Nature aging · 2025Article
- Laser-driven luminescent ceramic-converted near-infrared II light source for advanced imaging and detection techniques.Light, science & applications · 2025Article
- Injured renal cell membrane encapsulated ICG/CORM-401 for homologous targeted NIR theranostics of acute kidney injury.Journal of nanobiotechnology · 2025Article
- Complications of image-guided liver biopsies: Results of a nationwide database analysis.PloS one · 2025Article
- Studying Macrophages in the Murine Steatotic Liver Using Flow Cytometry and Confocal Microscopy.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning.Journal of biomedical optics · 2023Article
- NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy.Biosensors · 2023Article
- Fatty Acids and Bilirubin as Intrinsic Autofluorescence Serum Biomarkers of Drug Action in a Rat Model of Liver Ischemia and Reperfusion.Molecules (Basel, Switzerland) · 2023Article
- Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis.Theranostics · 2023Article
- Cellular senescence in cancer: clinical detection and prognostic implications.Journal of experimental & clinical cancer research : CR · 2022Review
- Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance.Nature communications · 2022Article
- Multimodal NASH prognosis using 3D imaging flow cytometry and artificial intelligence to characterize liver cells.Scientific reports · 2022Article
- Imaging in experimental models of diabetes.Acta diabetologica · 2022Review
Corrections and comments
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- Erratum issued
Authors and funding
16 authors at 6 institutions in 4 countries.
Funding
Abstract
Monitoring the progression of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging methods. Here, we show that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity. We also show that the near-infrared and shortwave-infrared fluorescence of lipofuscin can be used to monitor the progression and regression of liver necroinflammation and fibrosis in mouse models of non-alcoholic fatty liver disease and advanced fibrosis, as well as to detect non-alcoholic steatohepatitis and cirrhosis in biopsied samples of human liver tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.