ArticleNature biomedical engineering2020
Intravital three-dimensional bioprinting.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 212 citations in OpenAlex.
- Nuclear mechanotransduction: tools for mechanical perturbation and chromatin characterization.Nucleus (Austin, Tex.) · 2026Review
- Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Two-Photon 3D Printing of Functional Microstructures Inside Living Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Soft Robotics and Advanced Technologies for Minimally Invasive Bioprinting: The Future of Internal Organ Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Imaging-guided non-invasive in vivo acoustic printing: a new "surgery-as-printing" paradigm for precision medicine.Science China. Life sciences · 2026Article
- Article
- Upconversion Photoluminescence to Monitor Local Heat Release During Femtosecond Direct Laser Writing of Bioinks In Situ.Small methods · 2026Article
- The mechanical strain as a cross-linking agent for skeletal muscle ECM-derived hydrogels.Materials today. Bio · 2026Article
- [Repair and reconstruction of facial organ injuries: a perfect fit of structure and function].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Article
- A Pill That Prints-An Ingestible Bioprinter for Non-Invasive Structured Bioink Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Laser-assisted microbial culturomics.Nature communications · 2025Article
- Advanced cell-adaptable hydrogels for bioprinting.Bioactive materials · 2025Review
- Recent Advances in Handheld and Robotic Bioprinting Approach for Tissue Engineering.Advanced materials technologies · 2025Article
- Traceless Photopolymerization with Non-Pulsed Red Light Enables 3D-Printable Cell-Laden Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Structured Light Projection Using Image Guide Fibers for In Situ Photo-biofabrication.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Polydopamine-based Surface Modifications for Tissue Engineering and Biosensing: From Understanding Chemistry to Diverse Applications.JOM (Warrendale, Pa. : 1989) · 2025Article
- Prenatal VEGF Nanodelivery Reverses Congenital Diaphragmatic Hernia-associated Pulmonary Abnormalities.American journal of respiratory and critical care medicine · 2025Article
- Imaging-guided deep tissue in vivo sound printing.Science (New York, N.Y.) · 2025Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
Abstract
Fabrication of three-dimensional (3D) structures and functional tissues directly in live animals would enable minimally invasive surgical techniques for organ repair or reconstruction. Here, we show that 3D cell-laden photosensitive polymer hydrogels can be bioprinted across and within tissues of live mice, using bio-orthogonal two-photon cycloaddition and crosslinking of the polymers at wavelengths longer than 850 nm. Such intravital 3D bioprinting-which does not create by-products and takes advantage of commonly available multiphoton microscopes for the accurate positioning and orientation of the bioprinted structures into specific anatomical sites-enables the fabrication of complex structures inside tissues of live mice, including the dermis, skeletal muscle and brain. We also show that intravital 3D bioprinting of donor-muscle-derived stem cells under the epimysium of hindlimb muscle in mice leads to the de novo formation of myofibres in the mice. Intravital 3D bioprinting could serve as an in vivo alternative to conventional bioprinting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.