ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2020
Validation of a digital pathology system including remote review during the COVID-19 pandemic.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.
- Best Practice Recommendations for the Implementation of a Digital Pathology Workflow in the Anatomic Pathology Laboratory by the European Society of Digital and Integrative Pathology (ESDIP).Diagnostics (Basel, Switzerland) · 2021Guideline
- Practical considerations for pathologists when selecting digital pathology systems: an ESDIP guide.The Journal of pathology · 2026Review
- Supporting the Learning of Visual Perception Skills in Cytology Through a Computational Tool: Development and Evaluation Study.JMIR formative research · 2026Article
- Deployment of AI-driven automated quality control of whole-slide images in a large tertiary cancer center.Journal of pathology informatics · 2026Article
- Comparative analysis of whole-slide scanner tissue detection algorithms: Implications for scan area, scan time, and file size in high-volume digital pathology workflows.Journal of pathology informatics · 2026Article
- Challenges and opportunities of implementing open-source digital pathology in sub-Saharan Africa: Lessons learned from deploying QuPath for breast cancer biomarker assessment in Cameroon.Journal of pathology informatics · 2026Article
- The promise of artificial intelligence in diagnostic breast pathology.Virchows Archiv : an international journal of pathology · 2026Article
- Validation of Digital Cytology for Primary Diagnosis Across a Range of Specimen Types.Cytopathology : official journal of the British Society for Clinical Cytology · 2026Article
- Assessing postoperative pancreatic fistula risk: from subjective assessment to digital pathology-assisted quantitative precision.Gland surgery · 2026Article
- Telepathology and Mobile Health System for Province-Wide Pathology Consultation in Henan, China: Retrospective Evaluation Study.Journal of medical Internet research · 2026Observational
- Assessing the influence of two deep-learning assistance modes on pathologists in cancer identification.Diagnostic pathology · 2026Article
- Artificial intelligence in genitourinary pathology.Histopathology · 2026Review
- Bridging the digital pathology divide: reciprocal learning between high-resource and low-resource settings.BMJ digital health & AI · 2026Review
- The role of artificial intelligence-based foundation models and "copilots" in cancer pathology: potential and challenges.Journal of experimental & clinical cancer research : CR · 2025Review
- Roche Digital Pathology Dx whole slide imaging system is comparable to traditional microscopy for primary diagnosis in surgical pathology.American journal of clinical pathology · 2025Article
- Current Trends and Future Directions of Digital Pathology and Artificial Intelligence in Dermatopathology: A Scientometric-Based Review.Diagnostics (Basel, Switzerland) · 2025Review
- Digital slide scanning at scale: Comparison of whole slide imaging devices in a clinical setting.Journal of pathology informatics · 2025Article
- Automatic labels are as effective as manual labels in digital pathology images classification with deep learning.Journal of pathology informatics · 2025Article
- Automating Colon Polyp Classification in Digital Pathology by Evaluation of a "Machine Learning as a Service" AI Model: Algorithm Development and Validation Study.JMIR formative research · 2025Article
- An equivalency and efficiency study for one year digital pathology for clinical routine diagnostics in an accredited tertiary academic center.Virchows Archiv : an international journal of pathology · 2025Review
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 2 institutions in 1 country.
Funding
Abstract
Remote digital pathology allows healthcare systems to maintain pathology operations during public health emergencies. Existing Clinical Laboratory Improvement Amendments regulations require pathologists to electronically verify patient reports from a certified facility. During the 2019 pandemic of COVID-19 disease, caused by the SAR-CoV-2 virus, this requirement potentially exposes pathologists, their colleagues, and household members to the risk of becoming infected. Relaxation of government enforcement of this regulation allows pathologists to review and report pathology specimens from a remote, non-CLIA certified facility. The availability of digital pathology systems can facilitate remote microscopic diagnosis, although formal comprehensive (case-based) validation of remote digital diagnosis has not been reported. All glass slides representing routine clinical signout workload in surgical pathology subspecialties at Memorial Sloan Kettering Cancer Center were scanned on an Aperio GT450 at ×40 equivalent resolution (0.26 µm/pixel). Twelve pathologists from nine surgical pathology subspecialties remotely reviewed and reported complete pathology cases using a digital pathology system from a non-CLIA certified facility through a secure connection. Whole slide images were integrated to and launched within the laboratory information system to a custom vendor-agnostic, whole slide image viewer. Remote signouts utilized consumer-grade computers and monitors (monitor size, 13.3-42 in.; resolution, 1280 × 800-3840 × 2160 pixels) connecting to an institution clinical workstation via secure virtual private network. Pathologists subsequently reviewed all corresponding glass slides using a light microscope within the CLIA-certified department. Intraobserver concordance metrics included reporting elements of top-line diagnosis, margin status, lymphovascular and/or perineural invasion, pathology stage, and ancillary testing. The median whole slide image file size was 1.3 GB; scan time/slide averaged 90 s; and scanned tissue area averaged 612 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.