Evidence map›Paper›PMID 32572145›Full record

SynthesisJournal of human genetics2020

Strong association between the 12q24 locus and sweet taste preference in the Japanese population revealed by genome-wide meta-analysis.

Kaoru Kawafune, Tsuyoshi Hachiya, Shun Nogawa, Shoko Takahashi, Huijuan Jia, Kenji Saito, Hisanori Kato

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Nutrients · 2025
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  5. Article
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  7. Article
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  12. Association ofNutrients · 2022
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kaoru KawafuneGenequest Inc., Siba 5-29-11, Minato-ku, Tokyo, 108-0014, Japan.
Tsuyoshi HachiyaGenequest Inc., Siba 5-29-11, Minato-ku, Tokyo, 108-0014, Japan.
Shun NogawaGenequest Inc., Siba 5-29-11, Minato-ku, Tokyo, 108-0014, Japan.ORCID http://orcid.org/0000-0002-7169-3233
Shoko TakahashiGenequest Inc., Siba 5-29-11, Minato-ku, Tokyo, 108-0014, Japan.
Huijuan JiaDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
Kenji SaitoGenequest Inc., Siba 5-29-11, Minato-ku, Tokyo, 108-0014, Japan.
Hisanori KatoDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan. akatoq@mail.ecc.u-tokyo.ac.jp.
The University of Tokyo · JP

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 16K14920
6 · The paper itself

Abstract

The sweet taste preference of humans is an important adaptation to ensure the acquisition of carbohydrate nutrition; however, overconsumption of sweet foods can potentially lead to diseases such as obesity and diabetes. Although previous studies have suggested that interindividual variation of human sweet taste preference is heritable, genetic loci associated with the trait have yet to be fully elucidated. Here, we genotyped 12,312 Japanese participants using the HumanCore-12+ Custom BeadChip or the HumanCore-24 Custom BeadChip microarrays. The sweet taste preference of the participants was surveyed via an internet-based questionnaire, resulting in a five-point scale of sweet taste preference. The genome-wide meta-analysis of the Japanese participants revealed a strong association between the 12q24 locus and sweet taste preference scale (P = 2.8 × 10

Indexed as

Genome-Wide Association StudyAlcohol DrinkingAldehyde Dehydrogenase, MitochondrialChromosomes, Human, Pair 12FemaleGenetic LociGenetic Predisposition to DiseaseGenotypeHumansJapanMaleMiddle AgedPolymorphism, Single NucleotideTasteAldehyde Dehydrogenase, MitochondrialALDH2 protein, human

Identifiers

PMID32572145
OpenAlexW3035891360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.